Transmembrane redox signaling activates NF-kappa B in macrophages

被引:45
作者
Kaul, N [1 ]
Choi, J [1 ]
Forman, HJ [1 ]
机构
[1] UNIV SO CALIF, DEPT MOL PHARMACOL & TOXICOL, LOS ANGELES, CA 90033 USA
关键词
NF-kappa B; H2O2; signaling; ferricyanide; free radicals;
D O I
10.1016/S0891-5849(97)00209-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In macrophages, NF-kappa B can be activated by H2O2 generated by the respiratory burst or added exogenously. The mechanism of H2O2 signaling may involve changes in the cellular redox state or a redox reaction at the plasma membrane; however, the site of H2O2 action cannot be readily ascertained because of its membrane permeability. Ferricyanide, a nonpermeable redox active anion, activated NF-kappa B in the macrophage cell line, J774A.1. In contrast with exogenous H2O2, activation by ferricyanide did not correlate with net oxidation of NAD(P)H or glutathione, suggesting that a transplasma membrane redox reaction itself was the first signaling process in NF-kappa B activation. (C) 1997 Elsevier Science Inc.
引用
收藏
页码:202 / 207
页数:6
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