Ubiquitin and the synapse

被引：130

作者：

Hegde, AN

DiAntonio, A

机构：

[1] Wake Forest Univ Hlth Sci, Dept Neurobiol & Anat, Winston Salem, NC 27157 USA

[2] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2002年 / 3卷 / 11期

关键词：

D O I：

10.1038/nrn961

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Post-translational modification by the attachment of ubiquitin seems to have a crucial role in regulating synaptic structure and function. By controlling the stability, activity and localization of target proteins, this versatile regulatory system can shape the pattern, activity and plasticity of synaptic connections. Here, we discuss the myriad ways in which ubiquitin functions to sculpt synapses during development, and to remodel synapses for the acquisition and storage of memory.

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页码：854 / 861

页数：8

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