Assessment of reproducibility - automated and digital caliper ECG measurement in the Framingham Heart Study

被引:13
作者
Burke, Gordon M. [1 ]
Wang, Na [2 ]
Blease, Sue [3 ,4 ]
Levy, Daniel [3 ,4 ,5 ,6 ]
Magnani, Jared W. [3 ,4 ,7 ]
机构
[1] Boston Univ, Med Ctr, Dept Med, Boston, MA USA
[2] Boston Univ, Sch Publ Hlth, Data Coordinating Ctr, Boston, MA USA
[3] NHLBI, Framingham, MA USA
[4] Boston Univ, Framingham Heart Study, Framingham, MA USA
[5] NHLBI, Ctr Populat Studies, NIH, Bethesda, MD 20892 USA
[6] NHLBI, Div Intramural Res, NIH, Bethesda, MD 20892 USA
[7] Boston Univ, Dept Med, Sect Cardiovasc Med, Boston, MA 02215 USA
关键词
Electrocardiogram; Reproducibility; P waves; QRS complex; QT interval; LEFT-VENTRICULAR HYPERTROPHY;
D O I
10.1016/j.jelectrocard.2014.01.004
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Background: Digitized electrocardiography permits the rapid, automated quantification of electrocardiograms (ECGs) for analysis. Community- and population-based studies have increasingly integrated such data. Assessing the reproducibility of automated ECG measures with manual measures is a critical step in preparation for using automated measures for research purposes. We recently established an ECG repository of digitally recorded ECGs for the Framingham Heart Study and we sought to assess the reproducibility of automated and manual measures. Methods: We selected 185 digitally recorded ECGs from routine visits of Framingham Heart Study participants spanning from 1986 to 2012. We selected the following ECG measures for their relevance to clinical and epidemiologic research: P wave duration, P wave amplitude, and PR interval in lead II; QRS duration and R wave amplitude in lead V6; and QT interval in lead V5. We obtained automated values for each waveform, and used a digital caliper for manual measurements. Digital caliper measurements were repeated in a subset (n = 81) of the samples for intrarater assessment. Results: We calculated the intraclass correlation coefficient (ICC) values for the interrater and intrarater assessments. P wave duration had the lowest interrater ICC (r = 0.46) and lowest intrarater ICC (r = 0.57). R wave amplitude had the highest interrater and intrarater ICC (r = 0.98) indicating excellent reproducibility. The remaining measures had interrater and intrarater ICCs of r >= 0.81. Conclusions: The interrater reproducibility findings for P wave amplitude, PR interval, QT interval, QRS duration, and R wave amplitude were excellent. In contrast, the reproducibility of P wave duration was more modest. These findings indicate high reproducibility of most automated and manual ECG measurements. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:288 / 293
页数:6
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