The double-edged role of 12/15-lipoxygenase during inflammation and immunity

被引：99

作者：

Ackermann, Jochen A. ^{[1
,2
,3
]}

Hofheinz, Katharina ^{[1
,2
,3
]}

Zaiss, Mario M. ^{[1
,2
]}

Kroenke, Gerhard ^{[1
,2
,3
]}

机构：

[1] Univ Hosp Erlangen, Dept Internal Med 3, Erlangen, Germany

[2] Univ Hosp Erlangen, Inst Clin Immunol, Erlangen, Germany

[3] Univ Erlangen Nurnberg, Univ Hosp Erlangen, Nikolaus Fiebiger Ctr Mol Med, Erlangen, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2017年 / 1862卷 / 04期

关键词：

Lipoxygenase; Lipoxins; Macrophages; Inflammation; Resolution; Lipid oxidation; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; LOW-DENSITY-LIPOPROTEIN; FATTY LIVER-DISEASE; PROLIFERATOR-ACTIVATED RECEPTORS; ARACHIDONIC-ACID METABOLITES; BRONCHIAL EPITHELIAL-CELLS; E-DEFICIENT MICE; APOPTOTIC CELLS; LIPID MEDIATORS; LIPOXIN A(4);

D O I：

10.1016/j.bbalip.2016.07.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

12/15-Lipoxygenase (12/15-LOX) mediates the enzymatic oxidation of polyunsaturated fatty acids, thereby contributing to the generation of various bioactive lipid mediators. Although 12/15-LOX has been implicated in the pathogenesis of multiple chronic inflammatory diseases, its physiologic functions seem to include potent immune modulatory properties that physiologically contribute to the resolution of inflammation and the clearance of inflammation-associated tissue damage. This review aims to give a comprehensive overview about our current knowledge on the role of this enzyme during the regulation of inflammation and immunity. This article is part of a Special Issue entitled: Lipid modification and lipid peroxidation products in innate immunity and inflammation edited by Christoph J. Binder. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：371 / 381

页数：11

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