Linkage of Patr-AL to Patr-A and-B in the major histocompatibility complex of the common chimpanzee (Pan troglodytes)

被引:10
作者
Geller, R
Adams, EJ
Guethlein, LA
Little, AM
Madrigal, JA
Parham, P [1 ]
机构
[1] Stanford Univ, Sch Med, Dept Struct Biol, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Microbiol Immunol, Stanford, CA 94305 USA
[3] Royal Free Hosp, Anthony Nolan Bone Marrow Trust, Tissue Typing Serv, London NW3 2QG, England
关键词
MHC class I; Patr-AL; reference strand-mediated conformation analysis linkage analysis; chimpanzee;
D O I
10.1007/s00251-002-0452-x
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Patr-AL is a recently described gene found only in the common chimpanzee, but closely related in structure to the highly polymorphic Patr-A and HLA-A genes of the chimpanzee and human MHCs, respectively. Unlike Patr-A and HLA-A, the Patr-AL gene has little polymorphism and is not fixed in the chimpanzee genome. To determine whether Patr-AL is located in the MHC or elsewhere, we compared segregation of the Patr-AL gene with segregation of Patr-A and -B alleles in chimpanzee families. The results demonstrate that Patr-AL is an MHC class I gene present on different MHC haplotypes as defined by their combination of Patr-A and B alleles.
引用
收藏
页码:212 / 215
页数:4
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