ZAP and ZIP, a story to forget

被引:36
作者
Bliss, Tim V. P.
Collingridge, Graham L.
Laroche, Serge
机构
[1] Natl Inst Med Res, MRC, Div Neurophysiol, London NW7 1AA, England
[2] Univ Bristol, MRC, Ctr Synapt Plast, Bristol BS8 1TD, Avon, England
[3] Univ Paris 11, CNRS, UMR 8620, NAMC, F-91405 Orsay, France
基金
英国医学研究理事会;
关键词
D O I
10.1126/science.1132538
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
How are memories stored and retrieved? Long-awaited evidence shows directly that the strength of synaptic connections in hippocampal neurons underlies both processes.
引用
收藏
页码:1058 / 1059
页数:2
相关论文
共 14 条
[1]   LONG-LASTING POTENTIATION OF SYNAPTIC TRANSMISSION IN DENTATE AREA OF ANESTHETIZED RABBIT FOLLOWING STIMULATION OF PERFORANT PATH [J].
BLISS, TVP ;
LOMO, T .
JOURNAL OF PHYSIOLOGY-LONDON, 1973, 232 (02) :331-356
[2]   A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
BLISS, TVP ;
COLLINGRIDGE, GL .
NATURE, 1993, 361 (6407) :31-39
[3]   EXCITATORY AMINO-ACIDS IN SYNAPTIC TRANSMISSION IN THE SCHAFFER COLLATERAL COMMISSURAL PATHWAY OF THE RAT HIPPOCAMPUS [J].
COLLINGRIDGE, GL ;
KEHL, SJ ;
MCLENNAN, H .
JOURNAL OF PHYSIOLOGY-LONDON, 1983, 334 (JAN) :33-46
[4]   Involvement of the CA3-CA1 synapse in the acquisition of associative learning in behaving mice [J].
Gruart, A ;
Muñoz, MD ;
Delgado-García, JM .
JOURNAL OF NEUROSCIENCE, 2006, 26 (04) :1077-1087
[5]   Protein kinase Mζ synthesis from a brain mRNA encoding an independent protein kinase Cζ catalytic domain -: Implications for the molecular mechanism of memory [J].
Hernandez, AI ;
Blace, N ;
Crary, JF ;
Serrano, PA ;
Leitges, M ;
Libien, JM ;
Weinstein, G ;
Tcherapanov, A ;
Sacktor, TC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (41) :40305-40316
[6]   Memory formation: The sequence of biochemical events in the hippocampus and its connection to activity in other brain structures [J].
Izquierdo, I ;
Medina, JH .
NEUROBIOLOGY OF LEARNING AND MEMORY, 1997, 68 (03) :285-316
[7]   A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories [J].
Jones, MW ;
Errington, ML ;
French, PJ ;
Fine, A ;
Bliss, TVP ;
Garel, S ;
Charnay, P ;
Bozon, B ;
Laroche, S ;
Davis, S .
NATURE NEUROSCIENCE, 2001, 4 (03) :289-296
[8]   Protein kinase Mζ enhances excitatory synaptic transmission by increasing the number of active postsynaptic AMPA receptors [J].
Ling, DSF ;
Benardo, LS ;
Sacktor, TC .
HIPPOCAMPUS, 2006, 16 (05) :443-452
[9]   Protein kinase Mζ is necessary and sufficient for LTP maintenance [J].
Ling, DSF ;
Benardo, LS ;
Serrano, PA ;
Blace, N ;
Kelly, MT ;
Crary, JF ;
Sacktor, TC .
NATURE NEUROSCIENCE, 2002, 5 (04) :295-296
[10]   Synaptic plasticity and memory: An evaluation of the hypothesis [J].
Martin, SJ ;
Grimwood, PD ;
Morris, RGM .
ANNUAL REVIEW OF NEUROSCIENCE, 2000, 23 :649-711