Further Exploration of the Links Between Occupational Exposure and Chronic Obstructive Pulmonary Disease

被引：44

作者：

Blanc, Paul D. ^{[1
,2
,5
]}

Eisner, Mark D. ^{[1
,2
,5
]}

Earnest, Gillian ^{[1
]}

Trupin, Laura ^{[3
]}

Balmes, John R. ^{[1
,2
]}

Yelin, Edward H. ^{[3
,6
]}

Gregorich, Steven E. ^{[4
]}

Katz, Patricia P. ^{[3
,6
]}

机构：

[1] Univ Calif San Francisco, Dept Med, Div Occupat & Environm Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Med, Div Pulm & Crit Care Med, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Med, Div Rheumatol, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Med, Div Gen Internal Med, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA

[6] Univ Calif San Francisco, Inst Hlth Policy Studies, San Francisco, CA 94143 USA

来源：

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | 2009年 / 51卷 / 07期

关键词：

ASTHMA; MATRIX; BURDEN; DUST; COPD;

D O I：

10.1097/JOM.0b013e3181a7dd4e

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective: To examine occupational risk for Chronic Obstructive Pulmonary Disease (COPD). Methods: We randomly recruited 233 subjects aged 55 to 75 reporting a physician's diagnosis of COPD, emphysema, or chronic bronchitis. Interviews assessed cigarette smoking and longest held job, identifying exposure to vapors, gas, dust, or fumes (VGDF). Lung function was assessed in n = 138. Comparison data were derived from a sample of referents without COPD. Results: VGDF was reported in 123 (53%) of 233 cases versus 5 77 (34%) of 1709 referents. VGDF was associated with COPD (Odds Ratio [OR] 2.5; 95% CI = 1.9 to 3.4); the population attributable fraction was 32%. In the lung function subset, the FEV1/FVC was < 70% in 79 (57%); 35 (44%) reported VGDF associated with an OR = 1.6 (95% CI = 0.99 to 2.6) and population attributable fraction 17 %. Conclusions: These data support an important role for occupational exposures in COPD. (J Occup Environ Med. 2009;51:804-810)

引用

页码：804 / 810

页数：7

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