Diels-Alder approach to polysubstituted biaryls: Rapid entry to tri- and tetra-ortho-substituted phosphorus-containing biaryls

被引：61

作者：

Ashburn, Bradley O. ^{[1
]}

Carter, Rich G. ^{[1
]}

机构：

[1] Oregon State Univ, Dept Chem, Corvallis, OR 97331 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 40期

关键词：

biaryls; Diels-Alder reaction; Negishi coupling; palladium; phosphanes;

D O I：

10.1002/anie.200602683

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rapid construction: A Diels-Alder-based approach to the synthesis of highly functionalized biaryls from readily available precursors is disclosed. The utility of these biaryl templates in palladium-mediated couplings is explored along with subsequent reductions of the nitro and phosphine oxide moieties. Finally, initial application of a synthesized biaryl as a highly active ligand in palladium-mediated coupling is carried out. (Chemical Equation Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6737 / 6741

页数：5

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