Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis

被引:299
作者
Lara-Tejero, Maria
Sutterwala, Fayyaz S.
Ogura, Yasunori
Grant, Ethan P.
Bertin, John
Coyle, Anthony J.
Flavell, Richard A.
Galan, Jorge E.
机构
[1] Yale Univ, Sch Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA
[2] Yale Univ, Sch Med, Sect Infect Dis, New Haven, CT 06536 USA
[3] Yale Univ, Sch Med, Sect Immunobiol, Howard Hughes Med Inst, New Haven, CT 06536 USA
[4] Milennium Pharmaceut Inc, Cambridge, MA 02139 USA
关键词
D O I
10.1084/jem.20060206
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Caspase-1 is activated by a variety of stimuli after the assembly of the "inflammasome," an activating platform made up of a complex of the NOD-LRR family of proteins. Caspase-1 is required for the secretion of proinflammatory cytokines, such as interleukin ( IL)-1 beta and IL-18, and is involved in the control of many bacterial infections. Paradoxically, however, its absence has been reported to confer resistance to oral infection by Salmonella typhimurium. We show here that absence of caspase-1 or components of the inflammasome does not result in resistance to oral infection by S. typhimurium, but rather, leads to increased susceptibility to infection.
引用
收藏
页码:1407 / 1412
页数:6
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