Effects of cholinergic enhancement on visual stimulation, spatial attention, and spatial working memory

被引:137
作者
Bentley, P
Husain, M
Dolan, RJ
机构
[1] Wellcome Dept Imaging Neurosci, London WC1N 3BG, England
[2] Charing Cross Hosp, Dept Neurol, London W6 8RF, England
[3] Inst Cognit Neurosci, London WC1N 3AR, England
基金
英国惠康基金;
关键词
D O I
10.1016/S0896-6273(04)00145-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We compared behavioral and neural effects of cholinergic enhancement between spatial attention, spatial working memory (WM), and visual control tasks, using fMRI and the anticholinesterase physostigmine. Physostigmine speeded responses nonselectively but increased accuracy selectively for attention. Physostigmine also decreased activations to visual stimulation across all tasks within primary visual cortex, increased extrastriate occipital cortex activation selectively during maintained attention and WM encoding, and decreased parietal activation selectively during maintained attention. Finally, lateralization of occipital activation as a function of the visual hemifield toward which attention or memory was directed was decreased under physostigmine. In the case of attention, this effect correlated strongly with a decrease in a behavioral measure of selective spatial processing. Our results suggest that, while cholinergic enhancement facilitates visual attention by increasing activity in extrastriate cortex generally, it accomplishes this in a manner that reduces expectation-driven selective biasing of extrastriate cortex.
引用
收藏
页码:969 / 982
页数:14
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