Islet β cell failure in type 2 diabetes

被引：1331

作者：

Prentki, Marc

Nolan, Christopher J.

机构：

[1] Australian Natl Univ, Dept Endocrinol & Diabet, Canberra Hosp, Woden, ACT 2606, Australia

[2] Australian Natl Univ, Sch Med, Woden, ACT 2606, Australia

[3] Univ Montreal, Mol Nutr Unit, Montreal, PQ, Canada

[4] Univ Montreal, Montreal Diabet Res Ctr, Montreal, PQ, Canada

[5] Ctr Hosp Univ Montreal, Montreal, PQ, Canada

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2006年 / 116卷 / 07期

关键词：

D O I：

10.1172/JCI29103

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The major focus of this Review is on the mechanisms of islet P cell failure in the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise occurs within the context of P cell compensation for insulin resistance, consideration is also given to the mechanisms involved in the compensation process, including mechanisms for expansion of P cell mass and for enhanced P cell performance. The importance of genetic, intrauterine, and environmental factors in the determination of "susceptible" islets and overall risk for T2D is reviewed. The likely mechanisms of P cell failure are discussed within the two broad categories: those with initiation and those with progression roles.

引用

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页码：1802 / 1812

页数：11

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