Advances in dissecting mosquito innate immune responses to arbovirus infection

被引:93
作者
Fragkoudis, Rennos
Attarzadeh-Yazdi, Ghassem
Nash, Anthony A.
Fazakerley, John K.
Kohl, Alain [1 ]
机构
[1] Univ Edinburgh, Roslin Inst, Edinburgh EH9 1QH, Midlothian, Scotland
基金
英国惠康基金; 英国生物技术与生命科学研究理事会;
关键词
SEMLIKI-FOREST-VIRUS; WEST-NILE-VIRUS; DOUBLE-STRANDED-RNA; LA-CROSSE VIRUS; ANTIVIRAL IMMUNITY; ANOPHELES-GAMBIAE; DISEASE-VECTOR; CAPSID PROTEIN; AEDES-AEGYPTI; DENGUE VIRUS;
D O I
10.1099/vir.0.013201-0
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Arthropod-borne viruses - arboviruses - are a significant threat to public health. Whilst there is considerable knowledge about arbovirus interactions with vertebrate immunity, relatively little is known about how vectors such as mosquitoes control arbovirus infections. In this review, we discuss novel findings in the field of mosquito antiviral responses to arboviruses, in particular RNA interference, the up-and-coming field of general immune-signal ling pathways, and cell death/apoptosis.
引用
收藏
页码:2061 / 2072
页数:12
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