Ex vivo perfusion of the human placental cotyledon:: implications for anesthetic pharmacology

被引:57
作者
Ala-Kokko, TI
Myllynen, P
Vähäkangas, K
机构
[1] Univ Oulu, Dept Anesthesiol, FIN-90220 Oulu, Finland
[2] Univ Oulu, Dept Pharmacol & Toxicol, FIN-90220 Oulu, Finland
关键词
D O I
10.1054/ijoa.1999.0312
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Problems associated with extrapolating from animal to human; Problems associated with human clinical studies of placental transfer; Human placental perfusion model; Data presentation in human placental perfusions: Advantages and disadvantages of the cs vivo perfusion model; Distribution of drugs during placental perfusion: Effect of pH on transfer in placental perfusions; Effect of protein binding on transfer in placental perfusions, Summary and conclusions.
引用
收藏
页码:26 / 38
页数:13
相关论文
共 99 条
[1]   CALCIUM-TRANSPORT ACROSS THE ISOLATED DUALLY PERFUSED HUMAN PLACENTAL LOBULE [J].
ABRAMOVICH, DR ;
DACKE, CG ;
ELCOCK, C ;
PAGE, KR .
JOURNAL OF PHYSIOLOGY-LONDON, 1987, 382 :397-410
[2]  
AKBARALY R, 1981, J GYNECOL OBST BIO R, V10, P7
[3]  
ALAKOKKO T, 1997, ACTA UNIVERSITAS O D, V425
[4]   Transfer of clonidine and dexmedetomidine across the isolated perfused human placenta [J].
AlaKokko, TI ;
Pienimaki, P ;
Lampela, E ;
Hollmen, AI ;
Pelkonen, O ;
Vahakangas, K .
ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1997, 41 (02) :313-319
[5]   TRANSFER OF LIDOCAINE AND BUPIVACAINE ACROSS THE ISOLATED-PERFUSED HUMAN PLACENTA [J].
ALAKOKKO, TI ;
PIENIMAKI, P ;
HERVA, R ;
HOLLMEN, AI ;
PELKONEN, O ;
VAHAKANGAS, K .
PHARMACOLOGY & TOXICOLOGY, 1995, 77 (02) :142-148
[6]   TRANSFER OF HEPARIN ACROSS THE HUMAN PERFUSED PLACENTAL LOBULE [J].
BAJORIA, R ;
CONTRACTOR, SF .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1992, 44 (12) :952-959
[7]  
BARRE J, 1988, XENOBIOTICA, V18, P15
[8]  
Barzago MM, 1996, J PHARMACOL EXP THER, V277, P79
[9]   DETERMINANTS OF PLACENTAL DRUG TRANSFER - STUDIES IN THE ISOLATED-PERFUSED HUMAN PLACENTA [J].
BASSILY, M ;
GHABRIAL, H ;
SMALLWOOD, RA ;
MORGAN, DJ .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1995, 84 (09) :1054-1060
[10]   HUMAN PLACENTAL-TRANSFER OF ZINC - NORMAL CHARACTERISTICS AND ROLE OF ETHANOL [J].
BEER, WH ;
JOHNSON, RF ;
GUENTZEL, MN ;
LOZANO, J ;
HENDERSON, GI ;
SCHENKER, S .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1992, 16 (01) :98-105