Corticotropin-releasing hormone synthesizing neurons in the hypothalamic paraventricular nucleus of rats neonatally treated with monosodium glutamate can respond to different stress paradigms

被引:8
作者
Kiss, A [1 ]
Skultétyová, I [1 ]
Jezová, D [1 ]
机构
[1] Slovak Acad Sci, Inst Expt Endocrinol, SK-83306 Bratislava, Slovakia
关键词
monosodium glutamate; hypothalamic paraventricular nucleus; adrenalectomy; water deprivation; immobilization stress; CRH mRNA; POMC mRNA;
D O I
10.1080/01616412.1999.11741013
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Neonatal administration of monosodium glutamate (MSG) produces pathological lesions in many brain regions. There are indications that MSG treatment could also influence the neurons of the hypothalamic paraventricular nucleus (PVN). The goal of this study was to find out whether MSG treatment could alter the activity of the corticotropin-releasing hormone synthesizing neurons, i.e. the principal regulators of the corticotropin hormone secretion, located in the medial posterior subdivision of the PVN. The activity of CRH neurons was assessed by changes in CRH mRNA levels in response to both stimulatory and inhibitory conditions induced by immobilization and water deprivation, respectively. In addition, effect of the circulating glucocorticoid deficit induced by bilateral adrenalectomy was investigated. The obtained data show that in MSG-treated animals the rise in CRH mRNA in response to immobilization stress and adrenalectomy as well as the decrease after water deprivation were similar to the changes seen in controls. In addition POMC mRNA changes in MSG-treated animals indicate an uninterrupted capability of CRH neurons to transform different signals to corticotropin cells. It can be concluded that CRH neurons of the PVN are not functionally altered, in spite of the widespread neurotoxic effect of MSG treatment.
引用
收藏
页码:775 / 780
页数:6
相关论文
共 33 条
[1]  
Aguilera G, 1996, STRESS - MOLECULAR GENETIC AND NEUROBIOLOGICAL ADVANCES, VOLS 1 AMD 2, P385
[2]   REGULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS DURING WATER-DEPRIVATION [J].
AGUILERA, G ;
LIGHTMAN, SL ;
KISS, A .
ENDOCRINOLOGY, 1993, 132 (01) :241-248
[3]  
AGUILERA G, 1994, FRONT NEUROENDOCRIN, V15, P331
[4]   STRESS-INDUCED INCREASE IN VASOPRESSIN AND CORTICOTROPIN-RELEASING FACTOR EXPRESSION IN HYPOPHYSIOTROPHIC PARAVENTRICULAR NEURONS [J].
BARTANUSZ, V ;
JEZOVA, D ;
BERTINI, LT ;
TILDERS, FJH ;
AUBRY, JM ;
KISS, JZ .
ENDOCRINOLOGY, 1993, 132 (02) :895-902
[5]  
GERSTBERGER R, 1997, NEUROSCI LETT, V81, P193
[6]   PARADOXICAL RESPONSES OF HYPOTHALAMIC CORTICOTROPIN-RELEASING FACTOR (CRF) MESSENGER-RIBONUCLEIC-ACID (MESSENGER-RNA) AND CRF-41 PEPTIDE AND ADENOHYPOPHYSEAL PROOPIOMELANOCORTIN MESSENGER-RNA DURING CHRONIC INFLAMMATORY STRESS [J].
HARBUZ, MS ;
REES, RG ;
ECKLAND, D ;
JESSOP, DS ;
BREWERTON, D ;
LIGHTMAN, SL .
ENDOCRINOLOGY, 1992, 130 (03) :1394-1400
[7]   RESPONSES OF HYPOTHALAMIC AND PITUITARY MESSENGER-RNA TO PHYSICAL AND PSYCHOLOGICAL STRESS IN THE RAT [J].
HARBUZ, MS ;
LIGHTMAN, SL .
JOURNAL OF ENDOCRINOLOGY, 1989, 122 (03) :705-711
[8]   Hippocampal degeneration inducing impairment of learning in rats: Model of dementia? [J].
Ishikawa, K ;
Kubo, T ;
Shibanoki, S ;
Matsumoto, A ;
Hata, H ;
Asai, S .
BEHAVIOURAL BRAIN RESEARCH, 1997, 83 (1-2) :39-44
[9]   Effects of glutamate-induced excitotoxicity on calretinin-expressing neuron populations in the area postrema of the rat [J].
Jászai, J ;
Farkas, LM ;
Gallatz, K ;
Palkovits, M .
CELL AND TISSUE RESEARCH, 1998, 293 (02) :227-233
[10]  
JEZOVA D, 1987, ENDOCRINOLOGY, V120, P409