Veterans Aging Cohort Study (VACS) - Overview and description

被引:269
作者
Justice, Amy C.
Dombrowski, Elizabeth
Conigliaro, Joseph
Fultz, Shawn L.
Gibson, Deborah
Madenwald, Tamra
Goulet, Joseph
Simberkoff, Michael
Butt, Adeel A.
Rimland, David
Rodriguez-Barradas, Maria C.
Gibert, Cynthia L.
Oursler, Kris Ann K.
Brown, Sheldon
Leaf, David A.
Goetz, Matthew B.
Bryant, Kendall
机构
[1] VA Connecticut Healthcare Syst, West Haven, CT 06516 USA
[2] Yale Univ, Sch Med, Sect Gen Med, New Haven, CT USA
[3] Yale Univ, Sch Med, Dept Internal Med, Program Aging, New Haven, CT 06510 USA
[4] Univ Kentucky, Med Ctr, Lexington, KY USA
[5] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA
[6] NYU, Sch Med, New York, NY USA
[7] VA New York Harbor Healthcare Syst, New York, NY USA
[8] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA
[9] Univ Pittsburgh, Pittsburgh, PA USA
[10] Emory Univ, Sch Med, Atlanta, GA USA
[11] VA Med Ctr, Atlanta, GA USA
[12] Baylor Coll Med, Houston, TX 77030 USA
[13] Michael E DeBakey VAMC, Houston, TX USA
[14] George Washington Univ, Med Ctr, Washington, DC 20037 USA
[15] VA Med Ctr, Washington, DC USA
[16] Univ Maryland, Sch Med, Baltimore, MD 21201 USA
[17] Baltimore VA Med Ctr, Baltimore, MD USA
[18] Bronx Vet Adm Med Ctr, New York, NY USA
[19] Mt Sinai Sch Med, New York, NY USA
[20] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA USA
[21] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA
[22] NIAAA, HIV AIDS Res, Rockville, MD 20852 USA
关键词
HIV/AIDS; alcohol; aging veterans; data management/research design;
D O I
10.1097/01.mlr.0000223741.02074.66
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Background: The Veterans Aging Cohort Study (VACS) is a study of human immunodeficiency virus (HIV) infected and uninfected patients seen in infectious disease and general medical clinics. VACS includes the earlier 3 and 5 site studies (VACS 3 and VACS 5) as well as the ongoing 8 site study. Objectives: We sought to provide background and context for analyses based upon VACS data, including study design and rationale as well as its basic protocol and the baseline characteristics of the enrolled sample. Research Design: We undertook a prospectively consented multisite observational study of veterans in care with and without HIV infection. Measures: Data were derived from patient and provider self report, telephone interviews, blood and DNA samples, focus groups, and full access to the national VA "paperless" electronic medical record system. Results: More than 7200 veterans have been enrolled in at least one of the studies. The 8 site study (VACS) has enrolled 2979 HIV-infected and 3019 HIV-uninfected age-race-site matched comparators and has achieved stratified enrollment targets for race/ethnicity and age and 99% of its total target enrollment as of October 30, 2005. Participants in VACS are similar to other veterans receiving care within the VA. VACS participants are older and more predominantly black than those reported by the Centers for Disease Control. Conclusions: VACS has assembled a rich, in-depth, and representative sample of veterans in care with and without HIV infection to conduct longitudinal analyses of questions concerning the association between alcohol use and related comorbid and AIDS-defining conditions.
引用
收藏
页码:S13 / S24
页数:12
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