Carbonic anhydrase inhibitors: Inhibition studies of a coral secretory isoform with inorganic anions

被引：32

作者：

Bertucci, Anthony ^{[1
]}

Innocenti, Alessio ^{[2
]}

Zoccola, Didier ^{[1
]}

Scozzafava, Andrea ^{[2
]}

Allemand, Denis ^{[1
]}

Tambutte, Sylvie ^{[1
]}

Supuran, Claudiu T. ^{[2
]}

机构：

[1] Ctr Sci Monaco, MC-98000 Principality Monaco, Monaco

[2] Univ Florence, Dipartimento Chim, I-50019 Florence, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 03期

关键词：

Carbonic anhydrase; Coral; Enzyme inhibitor; Inorganic anion; Carbonate; Iodide; Biomineralization; ISOZYME-II; GALAXEA-FASCICULARIS; TRANSPORT METABOLON; IV; IX; CALCIFICATION; BIOMINERALIZATION; PHOTOSYNTHESIS; TRANSMEMBRANE; LOCALIZATION;

D O I：

10.1016/j.bmcl.2008.12.056

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The inhibition of a coral carbonic anhydrase ( CA, EC 4.2.1.1) has been investigated with a series of inorganic anions such as halogenides, pseudohalogenides, bicarbonate, carbonate, nitrate, nitrite, hydrogen sulfide, bisulfite, perchlorate, sulfate. The full-length scleractinian coral Stylophora pistillata CA, STPCA, has a significant catalytic activity for the physiological reaction of CO2 hydration to bicarbonate, similarly to the ubiquitous human isoforms hCA I ( cytosolic) and hCA VI ( secreted). The best STPCA anion inhibitors were bromide, iodide, carbonate, and sulfamate, with inhibition constants of 9.0-10.0 mu M. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：650 / 653

页数：4

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