Formation of guanosine adducts from L-ascorbic acid under oxidative conditions

被引：23

作者：

Larisch, B

Pischetsrieder, M

Severin, T

机构：

[1] Institute für Pharmazie, Lebensmittelchemie Univ. Munchen, D-80333 München

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(97)10056-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

L-Ascorbic acid (AA) was incubated with guanosine under physiological conditions and the reaction was monitored by HPLC-DAD. Four reaction products were isolated and identified as two pairs of diastereomers of N-2-(1-Carboxyethyl)-guanosine and N-2-(1-Carboxy-3-hydroxypropyl)-guanosine respectively. They were formed from AA in the presence of oxygen as well as from its degradation products L-dehydroascorbic acid and L-xylosone. (C) 1997 Elsevier Science Ltd.

引用

页码：2681 / 2686

页数：6

共 21 条

[1]

THE ROLE OF ASCORBIC-ACID IN SENILE CATARACT [J].