Total synthesis of (±)-perophoramidine

被引：153

作者：

Fuchs, JR ^{[1
]}

Funk, RL ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 16期

关键词：

D O I：

10.1021/ja049569g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first total synthesis of racemic perophoramidine is described. The key step features the highly stereoselective introduction of the vicinial quaternary centers via base-promoted carbon-carbon bond formation between a 3-alkylindole and a 3-bromo-3-alkylindolin-2-one. This transformation presumably proceeds through a conjugate addition or Diels-Alder cycloaddition of the 3-alkylindole with a 3-alkylindol-2-one intermediate. Copyright © 2003 American Chemical Society.

引用

页码：5068 / 5069

页数：2

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