amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge

被引：125

作者：

Goulding, SE ^{[1
]}

zur Lage, P ^{[1
]}

Jarman, AP ^{[1
]}

机构：

[1] Univ Edinburgh, Inst Cell & Mol Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

NEURON | 2000年 / 25卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0896-6273(00)80872-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In a variety of organisms, early neurogenesis requires the function of basic-helix-loop-helix (bHLH) transcription factors. For the Drosophila PNS, such transcription factors are encoded by the proneural genes (atonal and the achaete-scute complex, AS-C). We have identified a proneural gene, amos, that has strong similarity with atonal in its bHLH domain. We present evidence that amos is required for olfactory sensilla and is regulated by the prepattern gene lozenge. Between them, amos, atonal, and the AS-C can potentially account for the origin of the entire PNS.

引用

页码：69 / 78

页数：10

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