Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice

被引：132

作者：

Carlson, GA

Borchelt, DR

Dake, A

Turner, S

Danielson, V

Coffin, JD

Eckman, C

Meiners, J

Nilsen, SP

Younkin, SG

Hsiao, KK

机构：

[1] JOHNS HOPKINS UNIV,DEPT PATHOL,BALTIMORE,MD 21205

[2] MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

[3] UNIV MINNESOTA,DEPT NEUROL,MINNEAPOLIS,MN 55455

来源：

HUMAN MOLECULAR GENETICS | 1997年 / 6卷 / 11期

关键词：

D O I：

10.1093/hmg/6.11.1951

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Overexpression of Alzheimer amyloid precursor protein (APP) produces dramatically different phenotypes in transgenic mice depending on the genetic background, For example, concentrations of APP that produce amyloid plagues in outbred transgenic lines are lethal for inbred FVB/N or C57BL/6J mice, Expression of SOD1 transgenes is protective, suggesting involvement of oxidative damage in premature death, but ablation of Apoe had no significant effect, In contrast, FGF2 transgene overexpression enhances the lethal effects of APP. Differential survival does not appear to reflect genetic differences in APP processing, but rather host responses to APP or its derivatives.

引用

页码：1951 / 1959

页数：9

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