Alteration of serotonin transporter density and activity in fibromyalgia

被引:40
作者
Bazzichi, Laura
Giannaccini, Gino
Betti, Laura
Mascia, Giovanni
Fabbrini, Laura
Italiani, Paola
De Feo, Francesca
Giuliano, Tiziana
Giacomelli, Camillo
Rossi, Alessandra
Lucacchini, Antonio
Bombardieri, Stefano
机构
[1] Univ Pisa, Dept Psychiat Neurobiol Pharmacol & Biotechnol, I-56126 Pisa, Italy
[2] Univ Pisa, Dept Internal Med, Div Rheumatol, I-56126 Pisa, Italy
关键词
D O I
10.1186/ar1982
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The aim of the study was to evaluate the kinetic parameters of a specific serotonin transporter (SERT) and serotonin uptake in a mentally healthy subset of patients with fibromyalgia. Platelets were obtained from 40 patients and 38 healthy controls. SERT expression and functionality were evaluated through the measurement of [H-3] paroxetine binding and the [H-3] serotonin uptake itself. The values of maximal membrane binding capacity (B-max) were statistically lower in the patients than in the healthy volunteers, whereas the dissociation constant (K-d) did not show any statistically significant variations. Moreover, a decrease in the maximal uptake rate of SERT (V-max) was demonstrated in the platelets of patients, whereas the Michaelis constant (K-m) did not show any statistically significant variations. Symptom severity score ( tiredness, tender points index and Fibromyalgia Impact Questionnaire) were negatively correlated with B-max and with V-max, and positively correlated with K-m. A change in SERT seems to occur in fibromyalgic patients, and it seems to be related to the severity of fibromyalgic symptoms.
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页数:6
相关论文
共 44 条
[1]   5-HIAA AND HVA IN CSF IN PATIENTS WITH IDIOPATHIC PAIN DISORDERS [J].
ALMAY, BGL ;
HAGGENDAL, J ;
VONKNORRING, L ;
ORELAND, L .
BIOLOGICAL PSYCHIATRY, 1987, 22 (04) :403-412
[2]   A MODIFIED ASSAY-METHOD FOR DETERMINING SEROTONIN UPTAKE IN HUMAN-PLATELETS [J].
ARORA, RC ;
MELTZER, HY .
CLINICA CHIMICA ACTA, 1981, 112 (02) :225-233
[3]  
BURCKHARDT CS, 1991, J RHEUMATOL, V18, P728
[4]   Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene [J].
Caspi, A ;
Sugden, K ;
Moffitt, TE ;
Taylor, A ;
Craig, IW ;
Harrington, H ;
McClay, J ;
Mill, J ;
Martin, J ;
Braithwaite, A ;
Poulton, R .
SCIENCE, 2003, 301 (5631) :386-389
[5]   Guinea pig 5-HT transporter: cloning, expression, distribution, and function in intestinal sensory reception [J].
Chen, JX ;
Pan, H ;
Rothman, TP ;
Wade, PR ;
Gershon, MD .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1998, 275 (03) :G433-G448
[6]   Effects on muscle pain by intramuscular injection of granisetron in patients with fibromyalgia [J].
Ernberg, M ;
Lundeberg, T ;
Kopp, S .
PAIN, 2003, 101 (03) :275-282
[7]  
Ernberg M, 2000, J OROFAC PAIN, V14, P37
[8]  
First M.B., 2002, Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition (SCID-I/P)
[9]  
FISCHER AA, 1986, ARCH PHYS MED REHAB, V67, P406
[10]   A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia [J].
Goldenberg, D ;
Mayskiy, M ;
Mossey, C ;
Ruthazer, R ;
Schmid, C .
ARTHRITIS AND RHEUMATISM, 1996, 39 (11) :1852-1859