Impact of avolition and cognitive impairment on functional outcome in first-episode schizophrenia-spectrum disorder: a prospective one-year follow-up study

被引：46

作者：

Chang, Wing Chung ^{[1
,2
]}

Hui, Christy Lai Ming ^{[1
]}

Chan, Sherry Kit Wa ^{[1
,2
]}

Lee, Edwin Ho Ming ^{[1
]}

Chen, Eric Yu Hai ^{[1
,2
]}

机构：

[1] Univ Hong Kong, Dept Psychiat, Queen Mary Hosp, Pokfulam, Hong Kong, Peoples R China

[2] Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China

来源：

SCHIZOPHRENIA RESEARCH | 2016年 / 170卷 / 2-3期

关键词：

Motivational impairment; Negative symptoms; Functioning; First episode psychosis; SYNDROME SCALE PANSS; NEUROCOGNITIVE DEFICITS; NEGATIVE SYMPTOMS; APATHY; PREDICTION; DETERMINANTS; PSYCHOSIS; REMISSION; RECOVERY; PEOPLE;

D O I：

10.1016/j.schres.2016.01.004

中图分类号：

R749 [精神病学];

学科分类号：

100204 [神经病学];

摘要：

Previous research investigating the relationships between avolition, cognition and functioning in schizophrenia mostly focused on chronic samples and were cross-sectional in design. Impacts of avolition and cognition on longitudinal functional outcome in first-episode patients are under-studied. We assessed 114 Chinese aged 1055 years presenting with first-episode schizophrenia-spectrum disorder aiming to identify baseline predictors of 1-year functional outcome. Results showed that both avolition and global cognition independently predicted functioning, with avolition being the strongest predictor above and beyond cognition and other symptom dimensions. Our findings indicate the central role of in determining longitudinal functional status in the early illness stage. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：318 / 321

页数：4

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