Facile synthesis of mesoporous SBA-15 silica spheres and its application for high-performance liquid chromatography

被引:64
作者
Wan, Huihui [1 ,2 ]
Liu, Lin [1 ]
Li, Cunman [1 ,2 ]
Xue, Xingya [1 ]
Liang, Xinmiao [1 ]
机构
[1] Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
关键词
Mesoporous; SBA-15; silica; Spheres; Stationary phase; SIZE-EXCLUSION CHROMATOGRAPHY; MORPHOLOGICAL CONTROL; SPHERICAL-PARTICLES; STATIONARY-PHASE; HPLC; MCM-41; SURFACTANT; SEPARATION; COPOLYMER; TRIBLOCK;
D O I
10.1016/j.jcis.2009.05.065
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Micrometer-sized mesoporous SBA-15 silica spheres have been synthesized using triblock copolymer poly(ethyleneoxide)-block-poly(propyleneoxide)-block-poly(ethyleneoxide) (EO20PO70EO20) as structure-directing agent with the assistance of 1,3,5-trimethylbenzene and KCl. By controlling the composition of synthesis gel, SBA-15 silica spheres with particle size in the range of 2-4.5 mu m could be facilely obtained. The obtained SBA-15 silica spheres were characterized by X-ray diffraction, scanning electron microscopy, and N-2 physisorption technique. Dimethyloctadecylchlorosilane modified mesoporous SBA-15 silica with diameter of 4.5 mu m was explored as stationary phase in high-performance liquid chromatography, and its chromatographic characteristics for separation of some small molecules and relatively large bio-molecules have been studied. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:420 / 426
页数:7
相关论文
共 42 条
[1]  
BECK JS, 1992, J AM CHEM SOC, V114, P1083
[2]  
Boissière C, 2001, ADV FUNCT MATER, V11, P129, DOI 10.1002/1616-3028(200104)11:2<129::AID-ADFM129>3.3.CO
[3]  
2-N
[4]  
Gallis KW, 1999, ADV MATER, V11, P1452, DOI 10.1002/(SICI)1521-4095(199912)11:17<1452::AID-ADMA1452>3.3.CO
[5]  
2-I
[6]   Comparison of an ordered mesoporous aluminosilicate, silica, alumina, titania and zirconia in normal-phase high-performance liquid chromatography [J].
Grun, M ;
Kurganov, AA ;
Schacht, S ;
Schuth, F ;
Unger, KK .
JOURNAL OF CHROMATOGRAPHY A, 1996, 740 (01) :1-9
[7]   Spherical siliceous mesocellular foam particles for high-speed size exclusion chromatography [J].
Han, Yu ;
Lee, Su Seong ;
Ying, Jackie Y. .
CHEMISTRY OF MATERIALS, 2007, 19 (09) :2292-2298
[8]   Physico-chemical characterization of MCM-41 silica spheres made by the pseudomorphic route and grafted with octadecyl chains [J].
Kailasam, Kamalakannan ;
Mueller, Klaus .
JOURNAL OF CHROMATOGRAPHY A, 2008, 1191 (1-2) :125-135
[9]   Synthesis of ordered large pore SBA-15 spherical particles for adsorption of biomolecules [J].
Katiyar, Amit ;
Yadav, Santosh ;
Smirniotis, Panagiotis G. ;
Pinto, Neville G. .
JOURNAL OF CHROMATOGRAPHY A, 2006, 1122 (1-2) :13-20
[10]   Synthesis and characterization of hyperbranched mesoporous silica SBA-15 [J].
Kónya, Z ;
Zhu, J ;
Szegedi, A ;
Kiricsi, I ;
Alivisatos, P ;
Somorjai, GA .
CHEMICAL COMMUNICATIONS, 2003, (03) :314-315