Human unrestricted somatic stem cells ameliorate sepsis-related acute lung injury in mice

被引：17

作者：

Behjani, Zeinab Zarei ^{[1
]}

Ai, Jafar ^{[1
]}

Soleimani, Masoud ^{[2
,3
]}

Atashi, Amir ^{[4
]}

Taheri, Behnaz ^{[5
]}

Ebrahimi-Barough, Somayeh ^{[1
]}

Siavashi, Vahid ^{[6
]}

Shirian, Sadegh ^{[7
]}

Hamidieh, Amir Ali ^{[1
,8
]}

机构：

[1] Univ Tehran Med Sci, Fac Adv Technol Med, Dept Tissue Engn & Appl Cell Sci, Tehran, Iran

[2] Tarbiat Modares Univ, Hematol & Cell Therapy Dept, Fac Med Sci, Tehran, Iran

[3] Stem Cell Technol Res Ctr, Dept Stem Cell Biol, Tehran, Iran

[4] Shahroud Univ Med Sci, Stem Cell & Tissue Engn Res Ctr, Shahroud, Iran

[5] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Med Biotechnol, Tabriz, Iran

[6] Univ Tehran, Dept Clin Pathol, Fac Vet Med, Tehran, Iran

[7] Shahrekord Univ, Sch Vet Med, Dept Pathol, Shahrekord, Iran

[8] Univ Tehran Med Sci, Pediat Stem Cell Transplant Dept, Childrens Med Ctr, Tehran, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 08期

关键词：

acute lung injury; cell therapy; inflammation; umbilical cord; unrestricted somatic stem cells; CORD BLOOD; ANTIINFLAMMATORY RESPONSE; MYOCARDIAL-INFARCTION; TRANSPLANTATION; EXPRESSION; MORTALITY; PATHOLOGY; ENDOTOXIN; TRAUMA; LIVER;

D O I：

10.1002/jcp.28077

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Background AimsSepsis and related disorders, especially acute lung injury (ALI), are the most challenging life-threatening diseases in the hospital intensive care unit. Complex pathophysiology, unbalanced immune condition, and high rate of mortality complicate the treatment of sepsis. Recently, cell therapy has been introduced as a promising option to recover the sepsis symptoms. The aim of this study was to investigate the therapeutic potential of human unrestricted somatic stem cells (USSCs) isolated from human umbilical cord blood in the mouse model of ALI. USSCs significantly enhanced the survival rate of mice suffering from ALI and suppressed concentrations of proinflammatory mediators TNF-, and interleukin (IL)-6, and the level of anti-inflammatory cytokine IL-10. ALI mice injected by USSCs showed notable reduction in lung and liver injury, pulmonary edema, and hepatic enzymes, compared with the control group. These results determined the in vivo immunomodulatory effect of USSCs for recovery of immune balance and reduction of tissue injury in the mouse model of ALI. Therefore, USSCs can be a suitable therapeutic approach to manage sepsis disease through the anti-inflammatory potential.

引用

页码：13942 / 13950

页数：9

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