Growth/differentiation factor-5 induces angiogenesis in vivo

被引:95
作者
Yamashita, H
Shimizu, A
Kato, M
Nishitoh, H
Ichijo, H
Hanyu, A
Morita, I
Kimura, M
Makishima, F
Miyazono, K
机构
[1] UNIV TOKYO,FAC MED,DEPT OPHTHALMOL,BUNKYO KU,TOKYO 113,JAPAN
[2] TOKYO MED & DENT UNIV,GRAD SCH,DEPT PHYSIOL CHEM,BUNKYO KU,TOKYO 113,JAPAN
[3] NIPPON HOECHST MARION ROUSSEL LTD,DIV RES & DEV,DISCOVERY RES LABS,KAWAGOE,SAITAMA 35011,JAPAN
基金
日本学术振兴会;
关键词
D O I
10.1006/excr.1997.3664
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Bone morphogenetic proteins (BMPs) are multifunctional cytokines, which induce bone and cartilage formation and exert various other effects on many tissues, Since angiogenesis is involved in the bone formation process, certain members in the BMP family may induce angiogenesis. We examined the in vivo angiogenic activity of BMP family members, i.e., growth/differentiation factor (GDF)-5 and BMP-2, GDF-5 induced angiogenesis in both chick chorioallantoic membrane and rabbit cornea assays. In contrast BMP-2 did not induce angiogenesis. In order to elucidate the mechanism of angiogenesis, we examined the effects of GDF-5 on cultured bovine aortic endothelial cells (BECs). GDF-5 induced plasminogen activator activity and accelerated the migration of BECs in a chemotactic fashion, which may contribute to the process of angiogenesis in vivo. These results suggest that GDF-5 is one of the molecules which induce angiogenesis in the bone formation process. (C) 1997 Academic Press.
引用
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页码:218 / 226
页数:9
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