Carbohydrate triazoles and isoxazoles as inhibitors of galectins-1 and -3

被引：105

作者：

Giguere, Denis

Patnam, Ramesh

Bellefleur, Marc-Andre

St-Pierre, Christian

Sato, Sachiko

Roy, Rene

机构：

[1] Univ Quebec, Dept Chem, Montreal, PQ H3C 3P8, Canada

[2] Univ Laval, Fac Med, Res Ctr Infect Dis, Quebec City, PQ G1V 4G2, Canada

来源：

CHEMICAL COMMUNICATIONS | 2006年 / 22期

关键词：

D O I：

10.1039/b517529a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Galactosides and lactosides bearing triazoles or isoxazoles, regiospecifically prepared by [ 1,3]-dipolar cycloadditions between alkynes, azides or nitrile oxides, provided specific galectin-1 and - 3 inhibitors with potencies as low as 20 mu M.

引用

页码：2379 / 2381

页数：3

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