Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells

被引：2351

作者：

Le Blanc, K

Rasmusson, I

Sundberg, B

Götherström, C

Hassan, M

Uzunel, M

Ringdén, O

机构：

[1] Huddinge Univ Hosp, Div Clin Immunol, SE-14186 Stockholm, Sweden

[2] Huddinge Univ Hosp, Ctr Allogen Stem Cell Transplantat, SE-14186 Stockholm, Sweden

[3] Huddinge Univ Hosp, Karolinska Inst, Dept Haematol, SE-14186 Stockholm, Sweden

来源：

LANCET | 2004年 / 363卷 / 9419期

关键词：

D O I：

10.1016/S0140-6736(04)16104-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adult bone-marrow-derived mesenchymal stem cells are immunosuppressive and prolong the rejection of mismatched skin grafts in animals. We transplanted haploidentical mesenchymal stem cells in a patient with severe treatment-resistant grade IV acute graft-versus-host disease of the gut and liver. Clinical response was striking. The patient is now well after 1 year. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.

引用

页码：1439 / 1441

页数：3

共 5 条

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