Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops

被引：120

作者：

Murti, KG

Prescott, DM ^{[1
]}

机构：

[1] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA

[2] St Jude Childrens Res Hosp, Mol Biol & Virol Lab, Memphis, TN 38105 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1999年 / 96卷 / 25期

关键词：

D O I：

10.1073/pnas.96.25.14436

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The end of a telomeric DNA sequence isolated from a polytene chromosome of a hypotrichous ciliate folds back and hybridizes with downstream telomeric sequence to form a t loop that is stable in the absence of protein and DNA cross-linking. The single-stranded, telomeric DNA sequence at the end of a macronuclear molecule does not form a t loop but, instead, is complexed with a heterodimeric, telomere-binding protein. Thus, two mechanisms for capping the ends of DNA molecules are used in the same cell.

引用

页码：14436 / 14439

页数：4

共 19 条

[1]

[Anonymous], TELOMERES

[2] Telomeric localization of TRF2, a novel human telobox protein [J].