AMPA Receptor Subunits Get Their Share of the Pie

被引：11

作者：

Beique, Jean-Claude ^{[1
,2
]}

Huganir, Richard L. ^{[3
]}

机构：

[1] Univ Ottawa, Heart & Stroke Fdn, Ctr Stroke Recovery, Dept Cellular & Mol Med, Ottawa, ON K1H 8M5, Canada

[2] Univ Ottawa, Dept Cellular & Mol Med, Ctr Neural Dynam, Ottawa, ON K1H 8M5, Canada

[3] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept Neurosci, Baltimore, MD 21205 USA

来源：

NEURON | 2009年 / 62卷 / 02期

关键词：

SYNAPTIC PLASTICITY; EXCITATORY SYNAPSES; TRAFFICKING; NEURONS; GLUR2;

D O I：

10.1016/j.neuron.2009.04.016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Determining the precise subunit composition of AMPARs in situ has been an enduring challenge. In this issue of Neuron, Lu et al. make significant headway into this pesky problem by using a clever single-cell genetic knockout approach. In a Herculean effort, they provide the field with the completeness of a pie chart outlining the contribution of each AMPAR subunit to basal synaptic transmission at CA1 hippocampus synapses- and we get a pie chart for somatic extrasynaptic receptors, too.

引用

收藏

页码：165 / 168

页数：4

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