The ortho-substituted N,N-diacetylaniline as a selective acetylating reagent.

被引：38

作者：

Murakami, Y

Kondo, K

Miki, K

Akiyama, Y

Watanabe, T

Yokoyama, Y

机构：

[1] School of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(97)00745-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Selective acetylation of the less hindered amino group in the presence of the more hindered amino group with the use of 2-trifluoromethyl-N,N-diacetylaniline 2c is described. This acetylation with 2c yielded the corresponding less hindered monoacetamide exclusively, simply, conveniently, and in good yields. (C) 1997 Elsevier Science Ltd.

引用

页码：3751 / 3754

页数：4

共 26 条

[1]

ATKINSON RS, 1996, J CHEM SOC CHEM COMM, P1051

[2] EFFECT OF SUBSTITUENTS IN THE FORMATION OF DIACETANILIDES [J].