Successful "Medical" Orbital Decompression With Adjunctive Rituximab for Severe Visual Loss in IgG4-Related Orbital Inflammatory Disease With Orbital Myositis

被引：24

作者：

Chen, Tony Shang-Chuan ^{[1
,6
]}

Figueira, Edwin ^{[1
]}

Lau, Oliver C. F. ^{[1
]}

McKelvie, Penny A. ^{[4
]}

Smee, Robert I. ^{[5
]}

Dawes, Laughlin C. ^{[2
,3
]}

Agar, Ashish ^{[1
,6
]}

Wilcsek, Geoff ^{[1
]}

Francis, Ian C. ^{[1
,6
]}

机构：

[1] Prince Wales Hosp, Ocular Plast Unit, Dept Ophthalmol, Sydney, NSW 2031, Australia

[2] Prince Wales Hosp, Dept Med Imaging, Sydney, NSW 2031, Australia

[3] Sydney Childrens Hosp, Dept Med Imaging, Sydney, NSW, Australia

[4] St Vincents Hosp, Dept Histopathol, Melbourne, Vic, Australia

[5] Prince Wales Hosp, Dept Radiat Oncol, Sydney, NSW 2031, Australia

[6] Univ New S Wales, Prince Wales Clin Sch, Sydney, NSW, Australia

来源：

OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY | 2014年 / 30卷 / 05期

关键词：

COMPREHENSIVE DIAGNOSTIC-CRITERIA; AUTOIMMUNE PANCREATITIS; SYSTEMIC-DISEASE; IGG4-RD; DEPLETION; THERAPY; LATEST;

D O I：

10.1097/IOP.0b013e3182a64fa4

中图分类号：

R77 [眼科学];

学科分类号：

100212 [眼科学];

摘要：

IgG4-related disease (IgG4-RD) is an inflammatory condition of unknown etiology that can cause tumefactive lesions in a number of tissues and organs, including the orbit and ocular adnexa. Diagnostic criteria for IgG4-RD, including pathology and clinical features and pathology, have been recently proposed. 1 This study presents the first case of unilateral acute visual loss secondary to IgG4-related orbital inflammatory disease with orbital myositis that was complicated by severe compressive optic neuropathy. After initial treatment with pulsed intravenous methylprednisolone, followed by rituximab and radiotherapy, there was a marked improvement in orbital inflammation and clinical and radiological improvement in the compressive optic neuropathy. After (months of follow up, the orbital inflammatory disease remained in remission.

引用

页码：E122 / E125

页数：4

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