Enyne metathesis for the facile synthesis of highly functionalised novel bicyclic beta-lactams

被引:45
作者
Barrett, AGM [1 ]
Baugh, SPD [1 ]
Braddock, DC [1 ]
Flack, K [1 ]
Gibson, VC [1 ]
Procopiou, PA [1 ]
机构
[1] GLAXO WELLCOME RES & DEV LTD,DEPT MED CHEM,STEVENAGE SG1 2NY,HERTS,ENGLAND
关键词
D O I
10.1039/a702952g
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A wide range of bicyclic beta-lactam systems have been prepared via the enyne metathesis reaction using catalytic quantities of trans-(Cy3P)(2)Cl2Ru=CHPh (Cy = cyclo-hexyl).
引用
收藏
页码:1375 / 1376
页数:2
相关论文
共 18 条
[1]   Highly functionalised monocyclic and bicyclic beta-lactams via alkene metathesis [J].
Barrett, AGM ;
Baugh, SPD ;
Gibson, VC ;
Giles, MR ;
Marshall, EL ;
Procopiou, PA .
CHEMICAL COMMUNICATIONS, 1997, (02) :155-156
[2]   Alkene metathesis in the synthesis of novel beta-lactams [J].
Barrett, AGM ;
Baugh, SPD ;
Gibson, VC ;
Giles, MR ;
Marshall, EL ;
Procopiou, PA .
CHEMICAL COMMUNICATIONS, 1996, (19) :2231-2232
[3]   Tandem asymmetric allylboration-alkene metathesis: A novel strategy for the synthesis of trans-disubstituted homoallylic alcohols [J].
Barrett, AGM ;
Beall, JC ;
Gibson, VC ;
Giles, MR ;
Walker, GLP .
CHEMICAL COMMUNICATIONS, 1996, (19) :2229-2230
[4]   4-BENZOYLOXY-2-AZETIDINONE, A CONVENIENT SYNTHON FOR BETA-LACTAM INTERMEDIATES [J].
BASAK, A ;
KHAMRAI, U .
SYNTHETIC COMMUNICATIONS, 1994, 24 (02) :131-135
[5]   OLIVANIC ACID ANALOGS .1. TOTAL SYNTHESIS OF THE 7-OXO-1-AZABICYCLO[3.2.0]HEPT-2-ENE-2-CARBOXYLATE SYSTEM AND SOME RELATED BETA-LACTAMS [J].
BATESON, JH ;
BAXTER, AJG ;
ROBERTS, PM ;
SMALE, TC ;
SOUTHGATE, R .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1981, (12) :3242-3249
[6]   Studies toward a synthesis of epothilone A: Stereocontrolled assembly of the acyl region and models for macrocyclization [J].
Bertinato, P ;
Sorensen, EJ ;
Meng, DF ;
Danishefsky, SJ .
JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (23) :8000-8001
[7]  
Clark JS, 1997, TETRAHEDRON LETT, V38, P123
[8]   A concise total synthesis of dactylol via ring closing metathesis [J].
Furstner, A ;
Langemann, K .
JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (25) :8746-8749
[9]   RING-CLOSING METATHESIS AND RELATED PROCESSES IN ORGANIC-SYNTHESIS [J].
GRUBBS, RH ;
MILLER, SJ ;
FU, GC .
ACCOUNTS OF CHEMICAL RESEARCH, 1995, 28 (11) :446-452
[10]   Total synthesis of (-)-stemoamide using ruthenium-catalyzed enyne metathesis reaction [J].
Kinoshita, A ;
Mori, M .
JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (24) :8356-8357