Tissue factor in human coronary atherosclerotic plaques

被引：39

作者：

Ardissino, D

Merlini, PA

Arlens, R

Coppola, R

Bramucci, E

Lucreziotti, S

Repetto, A

Fetiveau, R

Mannucci, PM

机构：

[1] Policlin San Matteo, Div Cardiol, IRCCS, I-27100 Pavia, Italy

[2] Univ Pavia, I-27100 Pavia, Italy

[3] Niguarda Hosp, Div Cardiol 2, Milan, Italy

[4] Angelo Bianchi Bonomi Haemophilia & Thrombosis Ct, Milan, Italy

[5] Inst Internal Med, Milan, Italy

[6] Univ Milan, IRCCS, Maggiore Hosp, Milan, Italy

来源：

CLINICA CHIMICA ACTA | 2000年 / 291卷 / 02期

关键词：

coronary thrombosis; unstable angina; myocardial infarction; tissue factor;

D O I：

10.1016/S0009-8981(99)00231-4

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The rupture or fissuring of a coronary atherosclerotic plaque and subsequent thrombosis is considered the key event in the pathogenesis of unstable angina and myocardial infarction. Although plaque disruption frequently occurs during the evolution of atherosclerosis, only a minority of ruptured plaques develop thrombosis. The content and procoagulant activity of tissue factor in human coronary atherosclerotic plaques varies widely, and different studies confirm that it is higher in the plaques extracted from patients with unstable angina, myocardial infarction or histologic/angiographic evidence of coronary thrombosis than in those taken from patients with stable angina or uncomplicated coronary lesions. Variations in tissue factor content and activity may be responsible for the different thrombotic responses to human coronary atherosclerotic plaque rupture. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

引用

页码：235 / 240

页数：6

共 15 条

[1] DIFFERENTIAL EXPRESSION OF TISSUE FACTOR PROTEIN IN DIRECTIONAL ATHERECTOMY SPECIMENS FROM PATIENTS WITH STABLE AND UNSTABLE CORONARY SYNDROMES [J].