Three New Alkaloids from Galanthus nivalis and Galanthus elwesii

被引:15
作者
Berkov, Strahil [1 ]
Cuadrado, Maria [1 ]
Osorio, Edison [1 ]
Viladomat, Francesc [1 ]
Codina, Carles [1 ]
Bastida, Jaume [1 ]
机构
[1] Univ Barcelona, Fac Farm, Dept Prod Nat Biol Vegetal & Edafol, E-08028 Barcelona, Spain
关键词
Galanthus nivalis; Galanthus elwesii; Amaryllidaceae; alkaloids; 3,3 '-O-(3 ',3 ''-dihydroxybutanoyl)hamayne; 11,3 '-O-(3 ',3 ''-dihydroxybutanoyl)hamayne; 2-O-(3 '-hydroxybutanoyl)lycorine; AMARYLLIDACEAE ALKALOIDS;
D O I
10.1055/s-0029-1185575
中图分类号
Q94 [植物学];
学科分类号
071001 [植物学];
摘要
Phytochemical studies on Galanthus species resulted in the isolation of three new compounds: 3,3'-O-(3',3 ''-dihydroxybutanoyl)hamayne and 11,3'-O-(3',3 ''-dihydroxybutanoyl)hamayne from G. nivalis and 2-O-(3'-hydroxybutanoyl)lycorine from G. etwesii. Additionally, 3,11-O-(3',3 ''-dihydroxybutanoyl)hamayne, 3,11,3'-O-(3',3 '',3'''-trihydroxybutanoyl)hamayne, 8-O-demethylvasconine, tazettine, epimacronine, and ismine from G. nivalis; 2-O-(3'-acetoxybutanoyl)lycorine and incartine from G. elwesii; and hamayne, 11-O-(3'-hydroxybutanoyl)hamayne and lycorine from both species were isolated. Their structures were determined by EI-MS, HR-MS, CID, and 1D and 2D NMR (COSY, NOESY, HMQC, and HMBC) experiments.
引用
收藏
页码:1351 / 1355
页数:5
相关论文
共 12 条
[1]
ALKALOIDS FROM CRINUM-KIRKII [J].
BASTIDA, J ;
CODINA, C ;
PEETERS, P ;
RUBIRALTA, M ;
OROZCO, M ;
LUQUE, FJ ;
CHHABRA, SC .
PHYTOCHEMISTRY, 1995, 40 (04) :1291-1293
[2]
Bastida J, 2006, ALKALOIDS-CHEM BIOL, V63, P87, DOI 10.1016/S1099-4831(06)63003-4
[3]
Revised NMR data for incartine:: an alkaloid from Galanthus elwesii [J].
Berkov, Strahil ;
Reyes-Chilpa, Ricardo ;
Codina, Caries ;
Viladomat, Francesc ;
Bastida, Jaume .
MOLECULES, 2007, 12 (07) :1430-1435
[4]
Alkaloids from Galanthus nivalis [J].
Berkov, Strahil ;
Codina, Carles ;
Viladomat, Francesc ;
Bastida, Jaume .
PHYTOCHEMISTRY, 2007, 68 (13) :1791-1798
[5]
DEANGELIS GG, 1969, TETRAHEDRON LETT, V9, P729
[6]
Galanthamine from snowdrop - the development of a modern drug against Alzheimer's disease from local Caucasian knowledge [J].
Heinrich, M ;
Teoh, HL .
JOURNAL OF ETHNOPHARMACOLOGY, 2004, 92 (2-3) :147-162
[7]
KALASHNIKOV I D, 1970, KHIM PRIR SOEDIN (TASHK), V6, P380
[8]
Selective apoptosis-inducing activity of crinum-type Amaryllidaceae alkaloids [J].
McNulty, James ;
Nair, Jerald J. ;
Codina, Carles ;
Bastida, Jaume ;
Pandey, Siyaram ;
Gerasimoff, Jenny ;
Griffin, Carly .
PHYTOCHEMISTRY, 2007, 68 (07) :1068-1074
[9]
New lycorine-type alkaloid from Lycoris traubii and evaluation of antitrypanosomal and antimalarial activities of lycorine derivatives [J].
Toriizuka, Yosuke ;
Kinoshita, Eri ;
Kogure, Noriyuki ;
Kitajima, Mariko ;
Ishiyama, Aki ;
Otoguro, Kazuhiko ;
Yamada, Haruki ;
Omura, Satoshi ;
Takayama, Hiromitsu .
BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (24) :10182-10189
[10]
New skeletons and new concepts in Amaryllidaceae alkaloids [J].
Nehir Unver .
Phytochemistry Reviews, 2007, 6 (1) :125-135