Systemic lupus erythematosus

被引：628

作者：

D'Cruz, David P. ^{[1
]}

Khamashta, Munther A. ^{[1
]}

Hughes, Graham R. V. ^{[1
]}

机构：

[1] St Thomas Hosp, Rayne Inst, Lupus Res Unit, London SE1 7EH, England

来源：

LANCET | 2007年 / 369卷 / 9561期

关键词：

D O I：

10.1016/S0140-6736(07)60279-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Systemic lupus erythematosus is an autoimmune connective-tissue disorder with a wide range of clinical features, which predominantly affects women, especially from certain ethnic groups. Diagnosis is based on clinical assessment supported by investigations, including the finding of autoantibodies. Treatments range from antimalarial agents to corticosteroids and immunosuppressive agents. This Seminar draws attention to advances in the epidemiology, genetics, cardiovascular risks, lupus nephritis, CNS disease, the antiphospholipid syndrome, assessment of disease activity and damage, and pregnancy related and quality of life issues. New therapeutic approaches, such as biological agents and mycophenolate mofetil, will also be discussed.

引用

页码：587 / 596

页数：10

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