In vivo evaluation of a microneedle-based miniature syringe for intradermal drug delivery

被引：43

作者：

Hafeli, Urs O. ^{[4
]}

Mokhtari, Amir ^{[4
]}

Liepmann, Dorian ^{[3
]}

Stoeber, Boris ^{[1
,2
]}

机构：

[1] Univ British Columbia, Dept Mech Engn, Vancouver, BC V6T 1Z4, Canada

[2] Univ British Columbia, Dept Elect & Comp Engn, Vancouver, BC V6T 1Z4, Canada

[3] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA

[4] Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC V6T 1Z3, Canada

来源：

BIOMEDICAL MICRODEVICES | 2009年 / 11卷 / 05期

关键词：

Albumin; Drug delivery; MEMS syringe; Microneedles; Protein delivery; Skin; VACCINE;

D O I：

10.1007/s10544-009-9311-y

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

A microfabrication process for miniature syringes is described. The MEMS syringes consist of a silicon plate with an array of hollow out-of-plane needles and a flexible poly-dimethylsiloxane (PDMS) reservoir attached to the back of the plate. The PDMS reservoir can be filled with a drug solution or microparticle suspension which is delivered into the skin simply by the pressure of a finger pushing on the miniature syringe. The efficiency of such a syringe for delivering a suspension of microparticles into skin tissue and a radiolabelled protein (albumin) solution into live mice is reported. Such microneedle devices could be used for the intradermal delivery of vaccination agents or for the systemic delivery of highly effective drugs.

引用

页码：943 / 950

页数：8

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