Use of antibiotics to prevent preterm birth

被引:41
作者
Gibbs, RS [1 ]
Eschenbach, DA [1 ]
机构
[1] UNIV WASHINGTON,DEPT OBSTET & GYNECOL,SEATTLE,WA 98195
关键词
antibiotics; preterm birth; preterm premature rupture of membranes;
D O I
10.1016/S0002-9378(97)70201-1
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Our purpose is to review recent data and provide a clinical opinion on the use of antibiotics to prevent preterm birth or related maternal-neonatal complications. A literature review and a synthesis of opinion are provided. During prenatal care, standard practices should be applied regarding Neisseria gonorrhoeae, Chlamydia trachomatis, and bacteriuria. Ir addition, screen for and treat bacterial vaginosis in patients at high risk for preterm birth but do not treat Ureaplasma urealyticum or group B streptococci genital colonization. With preterm labor and intact membranes, standard practices should be applied regarding group B streptococci prophylaxis. Do not give antibiotics routinely to prolong pregnancy, but in patients with bacterial vaginosis and Trichomonas vaginalis specific treatment should be given. With preterm premature rupture of membranes, standard practices should be applied regarding group B streptococci prophylaxis, but additional antibiotics should also be given to prolong pregnancies at 24 to 32 weeks' gestation. Reported adverse effects have been few to date. However, increased diligence is needed for resistant organisms. In selected clinical settings antibiotic therapy is now indicated to prolong pregnancy and prevent maternal-neonatal complications associated with preterm birth.
引用
收藏
页码:375 / 380
页数:6
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