Scaling of titanium implants entrains inflammation-induced osteolysis

被引:103
作者
Eger, Michal [1 ]
Sterer, Nir [2 ]
Liron, Tamar [1 ]
Kohavi, David [2 ]
Gabet, Yankel [1 ]
机构
[1] Tel Aviv Univ, Sackler Fac Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, Israel
[2] Tel Aviv Univ, Goldschleger Sch Dent Med, Sackler Fac Med, Dept Prosthodont, IL-69978 Tel Aviv, Israel
基金
以色列科学基金会;
关键词
WEAR PARTICLES; MACROPHAGES; BONE;
D O I
10.1038/srep39612
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
With millions of new dental and orthopedic implants inserted annually, periprosthetic osteolysis becomes a major concern. In dentistry, peri-implantitis management includes cleaning using ultrasonic scaling. We examined whether ultrasonic scaling releases titanium particles and induces inflammation and osteolysis. Titanium discs with machined, sandblasted/acid-etched and sandblasted surfaces were subjected to ultrasonic scaling and we physically and chemically characterized the released particles. These particles induced a severe inflammatory response in macrophages and stimulated osteoclastogenesis. The number of released particles and their chemical composition and nanotopography had a significant effect on the inflammatory response. Sandblasted surfaces released the highest number of particles with the greatest nanoroughness properties. Particles from sandblasted/acid-etched discs induced a milder inflammatory response than those from sandblasted discs but a stronger inflammatory response than those from machined discs. Titanium particles were then embedded in fibrin membranes placed on mouse calvariae for 5 weeks. Using micro-CT, we observed that particles from sandblasted discs induced more osteolysis than those from sandblasted/acid-etched discs. In summary, ultrasonic scaling of titanium implants releases particles in a surface type-dependent manner and may aggravate peri-implantitis. Future studies should assess whether surface roughening affects the extent of released wear particles and aseptic loosening of orthopedic implants.
引用
收藏
页数:11
相关论文
共 24 条
[1]
Wear Particles Impair Antimicrobial Activity Via Suppression of Reactive Oxygen Species Generation and ERK1/2 Phosphorylation in Activated Macrophages [J].
Chen, Weishen ;
Li, Ziqing ;
Guo, Ying ;
Zhou, Yuhuan ;
Zhang, Yangchun ;
Luo, Guotian ;
Yang, Xing ;
Li, Chaohong ;
Liao, Weiming ;
Sheng, Puyi .
INFLAMMATION, 2015, 38 (03) :1289-1296
[2]
RETRACTED: Interventions for replacing missing teeth: different types of dental implants - art. no. CD003815.pub2 (Retracted Article) [J].
Esposito, M ;
Coulthard, P ;
Thomsen, P ;
Worthington, HV .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2005, (01)
[3]
Interventions for replacing missing teeth: treatment of periimplantitis [J].
Esposito, Marco ;
Grusovin, Maria Gabriella ;
Worthington, Helen V. .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2012, (01)
[4]
Pro-inflammatory responses of RAW264.7 macrophages when treated with ultralow concentrations of silver, titanium dioxide, and zinc oxide nanoparticles [J].
Giovanni, Marcella ;
Yue, Junqi ;
Zhang, Lifeng ;
Xie, Jianping ;
Ong, Choon Nam ;
Leong, David Tai .
JOURNAL OF HAZARDOUS MATERIALS, 2015, 297 :146-152
[5]
Consensus Statements and Clinical Recommendations for Prevention and Management of Biologic and Technical Implant Complications [J].
Heitz-Mayfield, Lisa J. A. ;
Needleman, Ian ;
Salvi, Giovanni E. ;
Pjetursson, Bjarni E. .
INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS, 2014, 29 :346-350
[6]
The Therapy of Peri-implantitis: A Systematic Review [J].
Heitz-Mayfield, Lisa J. A. ;
Mombelli, Andrea .
INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS, 2014, 29 :325-345
[7]
Direct three-dimensional morphometric analysis of human cancellous bone:: Microstructural data from spine, femur, iliac crest, and calcaneus [J].
Hildebrand, T ;
Laib, A ;
Müller, R ;
Dequeker, J ;
Rüegsegger, P .
JOURNAL OF BONE AND MINERAL RESEARCH, 1999, 14 (07) :1167-1174
[8]
Erythropoietin directly stimulates osteoclast precursors and induces bone loss [J].
Hiram-Bab, Sahar ;
Liron, Tamar ;
Deshet-Unger, Naamit ;
Mittelman, Moshe ;
Gassmann, Max ;
Rauner, Martina ;
Franke, Kristin ;
Wielockx, Ben ;
Neumann, Drorit ;
Gabet, Yankel .
FASEB JOURNAL, 2015, 29 (05) :1890-1900
[9]
The role of macrophages in osteolysis of total joint replacement [J].
Ingham, E ;
Fisher, J .
BIOMATERIALS, 2005, 26 (11) :1271-1286
[10]
Proinflammatory cytokine (TNFα/IL-1α) induction of human osteoclast formation [J].
Kudo, O ;
Fujikawa, Y ;
Itonaga, I ;
Sabokbar, A ;
Torisu, T ;
Athanasou, NA .
JOURNAL OF PATHOLOGY, 2002, 198 (02) :220-227