PARK2 polymorphisms predict disease progression in patients infected with hepatitis C virus

被引：4

作者：

Al-Qahtani, Ahmed A. ^{[1
,2
,8
]}

Al-Anazi, Mashael R. ^{[1
]}

Al-Zoghaibi, Fahad A. ^{[3
]}

Abdo, Ayman A. ^{[4
,8
]}

Sanai, Faisal M. ^{[5
,8
]}

Al-Hamoudi, Waleed K. ^{[4
,8
]}

Alswat, Khalid A. ^{[4
,8
]}

Al-Ashgar, Hamad I. ^{[6
]}

Khan, Mohammed Q. ^{[6
]}

Albenmousa, Ali ^{[7
]}

Khalak, Hanif ^{[9
]}

Al-Ahdal, Mohammed N. ^{[1
,2
,10
]}

机构：

[1] King Faisal Specialist Hosp & Res Ctr, Dept Infect & Immun, Res Ctr, Riyadh, Saudi Arabia

[2] Alfaisal Univ Sch Med, Dept Microbiol & Immunol, Riyadh, Saudi Arabia

[3] King Faisal Specialist Hosp & Res Ctr, Mol BioMed Program, Res Ctr, Riyadh, Saudi Arabia

[4] King Saud Univ, Gastroenterol Sect, Dept Med, Coll Med, Riyadh, Saudi Arabia

[5] King Abdul Aziz Med City, Dept Med, Gastroenterol Unit, Jeddah, Saudi Arabia

[6] King Faisal Specialist Hosp & Res Ctr, Dept Med, Gastroenterol Unit, Riyadh, Saudi Arabia

[7] Prince Sultan Med Mil City, Dept Gastroenterol, Riyadh, Saudi Arabia

[8] King Saud Univ, Liver Dis Res Ctr, Riyadh, Saudi Arabia

[9] Weill Cornell Med Coll, Adv Comp, Doha, Qatar

[10] King Faisal Specialist Hosp & Res Ctr, Dept Pathol & Lab Med, Riyadh, Saudi Arabia

来源：

ANNALS OF HEPATOLOGY | 2016年 / 15卷 / 06期

关键词：

PARK2; Single nucleotide polymorphism; HCV; HCC; Liver cirrhosis; RECESSIVE JUVENILE PARKINSONISM; T-CELL RESPONSE; VIRAL CLEARANCE; NATURAL-HISTORY; SAUDI-ARABIA; HCV; HEPATOCARCINOGENESIS; SUSCEPTIBILITY; GENE; ASSOCIATIONS;

D O I：

10.5604/16652681.1222097

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Background. The protein encoded by PARK2 gene is a component of the ubiquitin-proteasome system that mediates targeting of proteins for the degradation pathway. Genetic variations at PARK2 gene were linked to various diseases including leprosy, typhoid and cancer. The present study investigated the association of single nucleotide polymorphisms (SNPs) in the PARK2 gene with the development of hepatitis C virus (HCV) infection and its progression to severe liver diseases. Material and methods: A total of 800 subjects, including 400 normal healthy subjects and 400 HCV-infected patients, were analyzed in this study. The patients were classified as chronic HCV patients (group I), patients with cirrhosis (group II) and patients with hepatocellular carcinoma (HCC) in the context of cirrhosis (group III). DNA was extracted and was genotyped for the SNPs rs10945859, rs2803085, rs2276201 and rs1931223. Results: Among these SNPs, CT genotype of rs10945859 was found to have a significant association towards the clinical progression of chronic HCV infection to cirrhosis alone (OR = 1.850; 95% C. I. 1.115-3.069; p = 0.016) or cirrhosis and HCC (OR = 1.768; 95% C. I. 1.090-2.867; p value = 0.020). Conclusion: SNP rs10945859 in the PARK2 gene could prove useful in predicting the clinical outcome in HCV-infected patients.

引用

页码：824 / 833

页数：10

共 55 条

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