Prediction, Progression, and Outcomes of Chronic Kidney Disease in Older Adults

被引：162

作者：

Anderson, Sharon ^{[2
]}

Halter, Jeffrey B. ^{[3
]}

Hazzard, William R. ^{[4
,5
]}

Himmelfarb, Jonathan ^{[6
]}

Horne, Frances McFarland ^{[7
]}

Kaysen, George A. ^{[8
]}

Kusek, John W. ^{[9
]}

Nayfield, Susan G. ^{[10
]}

Schmader, Kenneth ^{[11
,12
]}

Tian, Ying ^{[10
]}

Ashworth, John R. ^{[7
]}

Clayton, Charles P. ^{[7
]}

Parker, Ryan P. ^{[7
]}

Tarver, Erika D. ^{[7
]}

Woolard, Nancy F.

High, Kevin P. ^{[1
]}

机构：

[1] Wake Forest Univ, Sch Med, Dept Internal Med, Infect Dis Sect, Winston Salem, NC 27157 USA

[2] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA

[3] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI USA

[4] Univ Washington, Dept Med, Seattle, WA USA

[5] VA Puget Sound Hlth Care Syst, Seattle, WA USA

[6] Maine Med Ctr, Dept Med, Portland, ME 04102 USA

[7] Assoc Specialty Professors, Washington, DC USA

[8] Univ Calif Davis, Dept Internal Med, Davis, CA 95616 USA

[9] NIDDKD, Kidney & Urol Branch, Bethesda, MD 20892 USA

[10] NIA, Geriatr & Clin Gerontol Branch, Bethesda, MD 20892 USA

[11] Duke Univ, Dept Med, Durham, NC USA

[12] Durham VA Med Ctr, Durham, NC USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2009年 / 20卷 / 06期

关键词：

STAGE RENAL-DISEASE; GLOMERULAR-FILTRATION-RATE; POLYUNSATURATED FATTY-ACIDS; CYCLE INHIBITOR P16(INK4A); URINARY ALBUMIN EXCRETION; TYPE-2; DIABETES-MELLITUS; LOW-DENSITY-LIPOPROTEIN; CYSTATIN-C; HEMODIALYSIS-PATIENTS; MORTALITY RISK;

D O I：

10.1681/ASN.2008080860

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic kidney disease is a large and growing problem among aging populations. Although progression of chronic kidney disease to end-stage renal disease (ESRD) is a costly and important clinical event with substantial morbidity, it appears less frequently in aging people compared with cardiovascular mortality. The measurement of kidney function and management of kidney disease in older individuals remain challenging, partly because the pathophysiologic mechanisms underlying age-related decline in kidney function, the interactions between age and other risk factors in renal progression, and the associations of chronic kidney disease with other comorbidities in older people are understudied and poorly understood. The Association of Specialty Professors, the American Society of Nephrology, the American Geriatrics Society, the National Institute on Aging, and the National Institute of Diabetes and Digestive and Kidney Diseases held a workshop, summarized in this article, to review what is known about chronic kidney disease, identify research gaps and resources available to address them, and identify priority areas for future research. Answers to emerging research questions will support the integration of geriatrics and nephrology and thus improve care for older patients at risk for chronic kidney disease.

引用

页码：1199 / 1209

页数：11

共 146 条

[1]

ABRASS CK, 1995, AM J PATHOL, V146, P742

[2]

Amann K, 1998, J AM SOC NEPHROL, V9, P1018

[3]

Amann K, 2000, J AM SOC NEPHROL, V11, P1702, DOI 10.1681/ASN.V1191702

[4]

[Anonymous], 2008, Am J Kidney Dis, V51, pS1

[5] Effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria [J].

Asselbergs, FW ;

Diercks, GFH ;

Hillege, HL ;

van Boven, AJ ;

Janssen, WMT ;

Voors, AA ;

de Zeeuw, D ;

de Jong, PE ;

van Veldhuisen, DJ ;

van Gilst, WH .

CIRCULATION, 2004, 110 (18) :2809-2816

[6] Association of kidney function with anemia - The Third National Health and Nutrition Examination Survey (1988-1994) [J].

Astor, BC ;

Muntner, P ;

Levin, A ;

Eustace, JA ;

Coresh, J .

ARCHIVES OF INTERNAL MEDICINE, 2002, 162 (12) :1401-1408

[7] Glomerular filtration rate, albuminuria, and risk of cardiovascular and all-cause mortality in the US population [J].

Astor, Brad C. ;

Hallan, Stein I. ;

Miller, Edgar R., III ;

Yeung, Edwina ;

Coresh, Josef .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2008, 167 (10) :1226-1234

[8] Erythropoietin regulates endothelial progenitor cells [J].

Bahlmann, FH ;

de Groot, K ;

Spandau, JM ;

Landry, AL ;

Hertel, B ;

Duckett, T ;

Boehm, SM ;

Menne, J ;

Haller, H ;

Fliser, D .

BLOOD, 2004, 103 (03) :921-926

[9] Chronic renal hypoxia after acute ischemic injury: effects of L-arginine on hypoxia and secondary damage [J].

Basile, DP ;

Donohoe, DL ;

Roethe, K ;

Mattson, DL .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2003, 284 (02) :F338-F348

[10] Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function [J].

Basile, DP ;

Donohoe, D ;

Roethe, K ;

Osborn, JL .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2001, 281 (05) :F887-F899

← 1 2 3 4 5 6 7 8 9 10 →