TNM staging of foregut (neuro)endocrine tumors:: a consensus proposal including a grading system

被引:1164
作者
Rindi, G.
Kloeppel, G.
Alhman, H.
Caplin, M.
Couvelard, A.
de Herder, W. W.
Erikssson, B.
Falchetti, A.
Falconi, M.
Komminoth, P.
Koerner, M.
Lopes, J. M.
McNicol, A-M.
Nilsson, O.
Perren, A.
Scarpa, A.
Scoazec, J. -Y
Wiedenmann, B.
机构
[1] Univ Parma, Dipartimento Patol & Med Lab, Sez Anat Patol, I-43100 Parma, Italy
[2] Univ Kiel, Dept Pathol, D-2300 Kiel, Germany
[3] Gothenburg Univ, Dept Surg, S-41124 Gothenburg, Sweden
[4] Royal Free Hosp, Dept Internal Med, London NW3 2QG, England
[5] Hop Beaujon, Dept Pathol, Clichy, France
[6] Dept Internal Med, Rotterdam, Netherlands
[7] Univ Uppsala Hosp, Dept Endocrinol, Uppsala, Sweden
[8] Univ Florence, Dept Internal Med, Florence, Italy
[9] Univ Verona, Dept Surg, I-37100 Verona, Italy
[10] Kantonsspital, Dept Pathol, Baden, Switzerland
[11] Univ Bern, Dept Pathol, CH-3000 Bern, Switzerland
[12] Univ Porto, Dept Pathol, Sch Med, P-4100 Oporto, Portugal
[13] Univ Porto, IPATIMUP, P-4100 Oporto, Portugal
[14] Glasgow Royal Infirm, Dept Pathol, Glasgow G4 0SF, Lanark, Scotland
[15] Gothenburg Univ, Dept Pathol, S-41124 Gothenburg, Sweden
[16] Univ Spital Zurich, Dept Pathol, Zurich, Switzerland
[17] Univ Verona, Dept Pathol, I-37100 Verona, Italy
[18] Univ Lyon, Dept Pathol, Lyon, France
[19] Dept Internal Med, Berlin, Germany
关键词
neuroendocrine tumors; gut; pancreas; staging; TNM; grading; mitotic index; Ki-67; index;
D O I
10.1007/s00428-006-0250-1
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The need for standards in the management of patients with endocrine tumors of the digestive system prompted the European Neuroendocrine Tumor Society (ENETS) to organize a first Consensus Conference, which was held in Frascati (Rome) and was based on the recently published ENETS guidelines on the diagnosis and treatment of digestive neuroendocrine tumors (NET). Here, we report the tumor-node-metastasis proposal for foregut NETs of the stomach, duodenum, and pancreas that was designed, discussed, and consensually approved at this conference. In addition, we report the proposal for a working formulation for the grading of digestive NETs based on mitotic count and Ki-67 index. This proposal, which needs to be validated, is meant to help clinicians in the stratification, treatment, and follow-up of patients.
引用
收藏
页码:395 / 401
页数:7
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