What is the true nature of the osteoblastic hematopoietic stem cell niche?

被引：72

作者：

Askmyr, Maria ^{[1
]}

Sims, Natalie A. ^{[1
,2
]}

Martin, T. John ^{[1
,2
]}

Purton, Louise E. ^{[1
,2
]}

机构：

[1] St Vincents Inst, Fitzroy, Vic 3065, Australia

[2] Univ Melbourne, Dept Med, Fitzroy, Vic 3065, Australia

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2009年 / 20卷 / 06期

关键词：

SYMPATHETIC-NERVOUS-SYSTEM; COLONY-STIMULATING FACTOR; BONE-LINING CELLS; PROGENITOR CELLS; N-CADHERIN; IN-VITRO; MARROW; RECEPTOR; MICE; MAINTENANCE;

D O I：

10.1016/j.tem.2009.03.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The recently revitalized interest in the regulation of hematopoietic stem cells (HSCs) by the bone marrow microenvironment has resulted in the identification of some important cell types that potentially form the HSC niche. The term 'osteoblast' has commonly been used to describe the endosteal elements of the HSC niche, but these cells are part of a larger family that functions in bone at different stages of differentiation. Given that there is much controversy as to what cell types have important roles in the HSC niche, this review offers an overview of the diverse osteoblastic cell types and discusses the current evidence regarding what roles they have in the HSC niche.

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收藏

页码：303 / 309

页数：7

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