Antinociceptive and hypothermic evaluation of the leaf essential oil and isolated terpenoids from Eugenia uniflora L. (Brazilian Pitanga)

被引：86

作者：

Amorim, Ana Carolina L. ^{[2
]}

Lima, Cleverton Kleiton F. ^{[1
]}

Hovell, Ana Maria C. ^{[2
]}

Miranda, Ana Luisa P. ^{[1
]}

Rezende, Claudia M. ^{[2
]}

机构：

[1] Univ Fed Rio de Janeiro, Fac Farm, Lab Avaliacao & Sintese Subst Bioat, Ctr Ciencias Saude, BR-21941902 Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Inst Quim, Ctr Tecnol, BR-21945970 Rio De Janeiro, Brazil

来源：

PHYTOMEDICINE | 2009年 / 16卷 / 10期

关键词：

Eugenia uniflora L; Essential oil; Anti nociceptive; Hypothermic; Furanosesquiterpenes;

D O I：

10.1016/j.phymed.2009.03.009

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eugenia uniflora L. (Myrtaceae), known as Brazilian cherry tree, is a fruity tree spread all over Brazil used in popular medicine to treat inflammations, rheumatic pain and fever, as hypoglycemic, diuretic and has been widely used in the cosmetics industry. The present study discusses the chemical composition, the antinociceptive and hypothermic profile of the essential oil of pitangueira leaves. The chemical composition was evaluated by GC-MS and the main constituent of the oil was characterized, after isolation, as a mixture of atractylone (1) and 3-furanoeudesmene (2). The essential oil, its pentane fraction and the isolated mixture of sesquiterpenes (1 and 2), given orally, significantly inhibited the acetic acid-induced abdominal constrictions, increased the latency time in hot plate test and showed a hypothermic effect. The results suggest that the responsible for the antinociceptive and hypothermic effect were the isolated furanosesquiterpenes. These findings provided additional pharmacological information and may contribute for the use of Brazilian cherry tree as a phytomedicine. (C) 2009 Elsevier GmbH. All rights reserved.

引用

页码：923 / 928

页数：6

共 24 条

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Adams R.P., 2004, Identification of Essential Oil Components by Gas Chromatography/Quadrupole Mass Spectroscopy

[2]

Auricchio Mariangela T., 2003, Revista do Instituto Adolfo Lutz, V62, P55

[3] Dimerization of butenolide structures.: A biomimetic approach to the dimeric sesquiterpene lactones (±)-biatractylolide and (±)-biepiasterolide [J].