Analysing the platelet transcriptome

被引：13

作者：

Macaulay, IC

Carr, P

Farrugia, R

Watkins, NA

机构：

[1] Univ Cambridge, Div Transfus Med, Cambridge CB2 2PT, England

[2] Natl Blood Serv Cambridge, Cambridge, England

来源：

VOX SANGUINIS | 2004年 / 87卷

关键词：

D O I：

10.1111/j.1741-6892.2004.00498.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

`Historical studies, using Northern blot hybridization, RT-PCR and cDNA library construction have demonstrated the presence of a variety of mRNA molecules in platelets. The development of microarray technology has allowed further characterization of the transcripts represented in the platelet transcriptome. In this review, these studies will be summarized and their findings in relation to the study of platelet function and the identification of disease risk genes discussed.

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页码：42 / 46

页数：5

相关论文

共 31 条

[1] METHOD FOR DETECTION OF SPECIFIC RNAS IN AGAROSE GELS BY TRANSFER TO DIAZOBENZYLOXYMETHYL-PAPER AND HYBRIDIZATION WITH DNA PROBES [J].

ALWINE, JC ;

KEMP, DJ ;

STARK, GR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) :5350-5354

[2] STUDIES ON HUMAN PLATELETS .1. SYNTHESIS OF PLATELET PROTEIN IN A CELL-FREE SYSTEM [J].

BOOYSE, FM ;

RAFELSON, ME .

BIOCHIMICA ET BIOPHYSICA ACTA, 1968, 166 (03) :689-&

[3] Exploring the new world of the genome with DNA microarrays [J].

Brown, PO ;

Botstein, D .

NATURE GENETICS, 1999, 21 (Suppl 1) :33-37

[4] THE EFFECT OF CHLORAMPHENICOL AND CYCLOHEXIMIDE ON PLATELET-AGGREGATION AND PROTEIN-SYNTHESIS [J].

BRUCE, IJ ;

KERRY, R .

BIOCHEMICAL PHARMACOLOGY, 1987, 36 (11) :1769-1773

[5]

Bugert P, 2003, THROMB HAEMOSTASIS, V90, P738

[6] Characterization of platelet-specific mRNA by real-time PCR after laser-assisted microdissection [J].

Fink, L ;

Höschermann, H ;

Kwapiszewska, G ;

Muyal, JP ;

Lengemann, B ;

Bohle, RM ;

Santoso, S .

THROMBOSIS AND HAEMOSTASIS, 2003, 90 (04) :749-756

[7] Transcript profiling of human platelets using microaray and serial analysis of gene expression [J].

Gnatenko, DV ;

Dunn, JJ ;

McCorkle, SR ;

Weissmann, D ;

Perrotta, PL ;

Bahou, WF .

BLOOD, 2003, 101 (06) :2285-2293

[8] BIOSYNTHESIS OF MAJOR PLATELET PROTEINS IN HUMAN-BLOOD PLATELETS [J].

KIEFFER, N ;

GUICHARD, J ;

FARCET, JP ;

VAINCHENKER, W ;

BRETONGORIUS, J .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1987, 164 (01) :189-195

[9] Analysis of matched mRNA measurements from two different microarray technologies [J].

Kuo, WP ;

Jenssen, TK ;

Butte, AJ ;

Ohno-Machado, L ;

Kohane, IS .

BIOINFORMATICS, 2002, 18 (03) :405-412

[10] Integrins regulate the intracellular distribution of eukaryotic initiation factor 4E in platelets - A checkpoint for translational control [J].

Lindemann, S ;

Tolley, ND ;

Eyre, JR ;

Kraiss, LW ;

Mahoney, TM ;

Weyrich, AS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (36) :33947-33951

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