No association found between polymorphisms in genes encoding mGluR7 and mGluR8 and idiopathic generalised epilepsy in a case control study

被引：14

作者：

Goodwin, H

Curran, N

Chioza, B

Blower, J

Nashef, L

Asherson, P

Makoff, AJ

机构：

[1] Inst Psychiat, Dept Psychol Med, London SE5 8AF, England

[2] Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, London SE7 8AF, England

[3] Kent & Canterbury Hosp, Dept Neurol, Canterbury CT1 3NG, Kent, England

[4] Kings Coll Hosp London, London SE5 9RS, England

来源：

EPILEPSY RESEARCH | 2000年 / 39卷 / 01期

基金：

英国医学研究理事会;

关键词：

metabotropic glutamate receptors; idiopathic generalised epilepsy; association study; polymorphism; variant;

D O I：

10.1016/S0920-1211(99)00096-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The genes of two group III metabotropic glutamate receptors, mGluR7 and 8, are candidate susceptibility genes for epilepsy. The Tyr433Phe polymorphism of mGluR7 and a novel polymorphism in the mGluR8 gene located 29 bp after the termination codon (2756C/T) were investigated in case control association studies performed on DNA from more than 100 patients with idiopathic generalised epilepsy (IGE). No significant association was found with IGE for either polymorphism. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

引用

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页码：27 / 31

页数：5

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