Expression, regulation and function of the homeobox gene empty spiracles in brain and ventral nerve cord development of Drosophila

被引：39

作者：

Hartmann, B

Hirth, F

Walldorf, U

Reichert, H

机构：

[1] Univ Basel, Inst Zool, CH-4051 Basel, Switzerland

[2] Univ Hohenheim, Inst Genet, D-70593 Stuttgart, Germany

来源：

MECHANISMS OF DEVELOPMENT | 2000年 / 90卷 / 02期

关键词：

ems; Emx2; gap genes; patterning genes; homeodomain proteins; insect proteins; brain development; ventral nerve cord; drosophila; animal; invertebrates; embryo; neurogenesis; neuroectoderm; deutocerebrum; tritocerebrum; neuroblasts; axogenesis; genetics; immunocytochemistry; enhancer analysis; mutants; transgenic animals; apoptosis; confocal microscopy; heat shock experiments; overexpression; mouse; rescue experiments; evolution;

D O I：

10.1016/S0925-4773(99)00237-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We analyse the role of the empty spiracles (ems) gene in embryonic brain and ventral nerve cord development. ems is differentially expressed in the neurectoderm of the anterior head versus the trunk region of tarry embryos. A distal enhancer region drives expression in the deutocerebral brain anlage and a proximal enhancer region drives expression in the VNC and tritocerebral brain anlage. Mutant analysis indicates that in the anterior brain ems is necessary for regionalized neurogenesis in the deutocerebral and tritocerebral anlagen. In the posterior brain and VNC ems is necessary for correct axonal pathfinding of specific interneurons. Rescue experiments indicate that the murine Emx2 gene can partially replace the fly ems gene in CNS development. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：143 / 153

页数：11

共 47 条

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