A multifunctional hydroquinone oxidase of the external cell surface and sera

被引:32
作者
Morré, DJ
Pogue, R
Morré, DM
机构
[1] Purdue Univ, Dept Med Chem & Mol Pharmaccol, W Lafayette, IN 47907 USA
[2] Purdue Univ, Dept Foods & Nutr, W Lafayette, IN 47907 USA
关键词
D O I
10.1002/biof.5520090213
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A multifunctional cell surface protein with NADH oxidase (NOX) activity and capable of oxidizing hydroquinones is located at the exterior of the cell and is shed in soluble form into sera. The oxidase appears to function as a terminal oxidase of a trans plasma membrane electron transport chain consisting of a NAD(P)H-ubiquinone reductase at the cytosolic membrane surface, possibly a b-type cytochrome, ubiquinone and the oxidase. Hyperactivity or conditions that interrupt ordered 2H(+) + 2e(-) transport from NAD(P)H or hydroquinone to molecular oxygen and other accepters at the external cell surface may result in the generation of superoxide. The latter may serve to propagate aging-related redox changes both to adjacent cells and circulating blood components. A circulating NOX activity form associated with aging and the reduction of cytochrome c by sera of aged patients that is partially inhibited by ubiquinone are described.
引用
收藏
页码:179 / 187
页数:9
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