Transcription factor fusions in acute leukemia: variations on a theme

被引：73

作者：

Scandura, JM ^{[1
]}

Boccuni, P ^{[1
]}

Cammenga, J ^{[1
]}

Nimer, SD ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Lab Mol Aspects Hematopoiesis, New York, NY 10021 USA

来源：

ONCOGENE | 2002年 / 21卷 / 21期

关键词：

leukemia; transcription; PML; RAR alpha; TGF beta; NUP98; AML1/ETO; CBF beta;

D O I：

10.1038/sj.onc.1205315

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The leukemia-associated fusion proteins share several structural or functional similarities, suggesting that they may impart a leukemic phenotype through common modes of transcriptional dysregulation. The fusion proteins generated by these translocations usually contain a DNA-binding domain, domains responsible for homo- or hetero-dimerization, and domains that interact with proteins involved in chromatin remodeling (e.g., corepressor molecules or co-activator molecules). It is these shared features that constitute the 'variations on the theme' that underling the aberrant growth and differentiation that is the hallmark of acute leukemia cells.

引用

页码：3422 / 3444

页数：23

共 295 条

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