Spatial compartmentalization in the regulation of glucose metabolism by insulin

被引：13

作者：

Brady, MJ

Pessin, JE

Saltiel, AR

机构：

[1] Warner Lambert Parke Davis, Parke Davis Pharmaceut Res Div, Dept Cell Biol, Ann Arbor, MI 48105 USA

[2] Univ Iowa, Dept Physiol & Biophys, Iowa City, IA 52242 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1999年 / 10卷 / 10期

关键词：

D O I：

10.1016/S1043-2760(99)00201-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Despite intense investigation, major gaps remain in our understanding of the cellular mechanisms that underlie the actions of insulin, as well as the regulation of the enzymes and transport proteins crucial to the orderly control of glucose metabolism. In recent years, the compartmentalization of signaling molecules and metabolic enzymes has been suggested to play an important role in ensuring metabolic balance. We will discuss examples of recent findings, suggesting that spatial compartmentalization and protein translocation might be the keys to understanding the specificity of insulin in the regulation of glucose metabolism.

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收藏

页码：408 / 413

页数：6

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