The Treatment-Naive Microbiome in New-Onset Crohn's Disease

被引：2361

作者：

Gevers, Dirk ^{[1
]}

Kugathasan, Subra ^{[6
]}

Denson, Lee A. ^{[7
]}

Vazquez-Baeza, Yoshiki ^{[8
]}

Van Treuren, Will ^{[9
]}

Ren, Boyu ^{[10
]}

Schwager, Emma ^{[10
]}

Knights, Dan ^{[11
,12
]}

Song, Se Jin ^{[9
]}

Yassour, Moran ^{[1
]}

Morgan, Xochitl C. ^{[10
]}

Kostic, Aleksandar D. ^{[1
]}

Luo, Chengwei ^{[1
]}

Gonzalez, Antonio ^{[9
]}

McDonald, Daniel ^{[9
]}

Haberman, Yael ^{[7
]}

Walters, Thomas ^{[13
]}

Baker, Susan ^{[14
]}

Rosh, Joel ^{[15
]}

Stephens, Michael ^{[16
]}

Heyman, Melvin ^{[17
]}

Markowitz, James ^{[18
]}

Baldassano, Robert ^{[19
]}

Griffiths, Anne ^{[20
]}

Sylvester, Francisco ^{[21
]}

Mack, David ^{[22
]}

Kim, Sandra ^{[23
]}

Crandall, Wallace ^{[23
]}

Hyams, Jeffrey ^{[21
]}

Huttenhower, Curtis ^{[1
,10
]}

Knight, Rob ^{[9
,24
,25
]}

Xavier, Ramnik J. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[2] Massachusetts Gen Hosp, Gastrointestinal Unit, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Ctr Study Inflammatory Bowel Dis, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA 02114 USA

[5] Harvard Univ, Sch Med, Boston, MA 02114 USA

[6] Emory Univ, Dept Pediat, Div Gastroenterol Hepatol & Nutr, Atlanta, GA 30322 USA

[7] Cincinnati Childrens Hosp, Med Ctr, Div Gastroenterol Hepatol & Nutr, Cincinnati, OH 45229 USA

[8] Univ Colorado, Dept Comp Sci, Boulder, CO 80309 USA

[9] Univ Colorado, BioFrontiers Inst, Boulder, CO 80309 USA

[10] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[11] Univ Minnesota, Dept Comp Sci & Engn, Minneapolis, MN 55108 USA

[12] Univ Minnesota, Inst Biotechnol, St Paul, MN 55108 USA

[13] Univ Toronto, Hosp Sick Children, Div Gastroenterol Hepatol & Nutr, Toronto, ON M5G IX8, Canada

[14] Childrens Hosp Buffalo, Buffalo, NY 14222 USA

[15] Goryeb Childrens Hosp, Morristown, NJ 07960 USA

[16] Mayo Clin, Rochester, MN 55902 USA

[17] Univ Calif San Francisco, San Francisco, CA 94143 USA

[18] North Shore Long Isl Jewish Med Ctr, New Hyde Pk, NY 11040 USA

[19] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

[20] Hosp Sick Children, Toronto, ON M5G IX8, Canada

[21] Connecticut Childrens Med Ctr, Hartford, CT 06106 USA

[22] Childrens Hosp Eastern Ontario, Ottawa, ON K1H 8L1, Canada

[23] Nationwide Childrens Hosp, Columbus, OH 43228 USA

[24] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

[25] Howard Hughes Med Inst, Boulder, CO 80309 USA

来源：

CELL HOST & MICROBE | 2014年 / 15卷 / 03期

关键词：

GUT MICROBIOME;

D O I：

10.1016/j.chom.2014.02.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Inflammatory bowel diseases (IBDs), including Crohn's disease (CD), are genetically linked to host pathways that implicate an underlying role for aberrant immune responses to intestinal microbiota. However, patterns of gut microbiome dysbiosis in IBD patients are inconsistent among published studies. Using samples from multiple gastrointestinal locations collected prior to treatment in new-onset cases, we studied the microbiome in the largest pediatric CD cohort to date. An axis defined by an increased abundance in bacteria which include Enterobacteriaceae, Pasteurellacaea, Veillonellaceae, and Fusobacteriaceae, and decreased abundance in Erysipelotrichales, Bacteroidales, and Clostridiales, correlates strongly with disease status. Microbiome comparison between CD patients with and without antibiotic exposure indicates that antibiotic use amplifies the microbial dysbiosis associated with CD. Comparing the microbial signatures between the ileum, the rectum, and fecal samples indicates that at this early stage of disease, assessing the rectal mucosal-associated microbiome offers unique potential for convenient and early diagnosis of CD.

引用

页码：382 / 392

页数：11

共 40 条

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